Natural Products Research at Latvian Institute of Organic Synthesis as a driver for Excellence in Innovation

Informazioni relative al progetto

Natalion

ID dell’accordo di sovvenzione: 101087181

DOI

10.3030/101087181

Data della firma CE 11 Ottobre 2022

Data di avvio 1 Gennaio 2023

Data di completamento 31 Dicembre 2027

Finanziato da

• Widening participation and spreading excellence

Costo totale

€ 2 499 950,00

Contributo UE

€ 2 499 950,00

Coordinato da

LATVIJAS ORGANISKAS SINTEZES INSTITUTS
Latvia

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Data Management Plan (1)

Natalion Data Management plan

Websites, patent fillings, videos etc. (2)

Report (1) on PEDR update and progress

Report on PEDR update and progress

Report (2) on PEDR update and progress

Report on PEDR update and progress

Documents, reports (2)

Operational report (1) of LIOS Innovation hub (incl. report on service package, training and interrelation build up)

Operational report of LIOS Innovation hub (incl. report on service package, training and interrelation build up)

Report on establishment and launching of LIOS Innovation hub

Pubblicazioni

Peer reviewed articles (12)

Radical SAM Enzyme WprB Catalyzes Uniform Cross-Link Topology between Trp-C5 and Arg-Cγ on the Precursor Peptide

Autori: Abujunaid Habib Khan, Jabal Rahmat Haedar, Vic Kiselov, Viktors Romanuks, Gints Smits, Stefano Donadio, Chin-Soon Phan
Pubblicato in: ACS Chemical Biology, Numero 20, 2025, ISSN 1554-8929
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACSCHEMBIO.4C00693

The Advancement of Peptides Derived from Kitasatospora

Autori: Jabal Rahmat Haedar, Abujunaid Habib Khan, Anitra Zīle, Chin-Soon Phan
Pubblicato in: Chemistry & Biodiversity, 2024, ISSN 1612-1872
Editore: Wiley
DOI: 10.1002/cbdv.202402999

Sequence-function space of radical SAM cyclophane synthases reveal conserved active site residues that influence substrate specificity

Autori: Chin-Soon Phan, Brandon I. Morinaka
Pubblicato in: RSC Chemical Biology, Numero 5, 2024, ISSN 2633-0679
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4cb00227j

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

Autori: Zdouc, M. M. et. al.
Pubblicato in: Nucleic Acids Research, 2024, ISSN 1362-4962
Editore: Oxford Academic
DOI: 10.1093/NAR/GKAE1115

Cyanobacterial Cyclic Peptides Containing <i>cis</i> ‐Pro Conformation

Autori: Jabal Rahmat Haedar, Abujunaid Habib Khan, Christopher R. Coxon, Chin‐Soon Phan
Pubblicato in: Chemistry – A European Journal, 2026, ISSN 0947-6539
Editore: Wiley
DOI: 10.1002/CHEM.202502932

P450 cyptide synthase MpoB catalyzes the cross-linking of the YPW motif on the precursor peptide

Autori: Abujunaid Habib Khan, Jabal Rahmat Haedar, Vic Kiselov, Viktors Romanuks, Gints Smits, Stefano Donadio, Chin-Soon Phan
Pubblicato in: RSC Chemical Biology, 2025, ISSN 2633-0679
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5CB00153F

Recent advancement of cyanobactins and cyanobactin prenyltransferases from 2021 to 2024

Autori: Abujunaid Habib Khan, Chin-Soon Phan
Pubblicato in: Frontiers in Natural Products, Numero 4, 2025, ISSN 2813-2602
Editore: Frontiers Media SA
DOI: 10.3389/FNTPR.2025.1616031

P450 Cyptide Synthase AscB Catalyzes Fused Cyclophane at the YxWxH Motif on the Precursor Peptides

Autori: Jabal Rahmat Haedar, Abujunaid Habib Khan, Jemma Gullick, Mathias H. Hansen, Laura J. Coe, James J. De Voss, Viktors Romanuks, Gints Smits, Stefano Donadio, Max J. Cryle, Chin-Soon Phan
Pubblicato in: Organic Letters, Numero 28, 2026, ISSN 1523-7060
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.ORGLETT.6C01044

Radical SAM cyclophane synthase catalyzes uniform cyclophane formation at multiple Trp-motifs

Autori: Abujunaid Habib Khan, Jabal Rahmat Haedar, Anitra Zīle, Chin-Soon Phan
Pubblicato in: Tetrahedron Chem, Numero 14, 2025, ISSN 2666-951X
Editore: Elsevier BV
DOI: 10.1016/J.TCHEM.2025.100128

S9 protease WprP2 catalyzes uniform cleavage on the precursor peptide in RiPP biosynthesis

Autori: Jabal Rahmat Haedar, Abujunaid Habib Khan, Suze Ma, Stefano Donadio, Chin-Soon Phan
Pubblicato in: Communications Chemistry, 2026, ISSN 2399-3669
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S42004-026-01915-W

P450 Cyptide Synthase KwwB Catalyzes Trp-C5–Trp-N1 Cross-Linking and Accepts Diverse Precursor Peptides

Autori: Jabal Rahmat Haedar, Gaja Swarna Kumari, Vic Kiselov, Viktors Romanuks, Gints Smits, Stefano Donadio, Chin-Soon Phan
Pubblicato in: Organic Letters, 2025, ISSN 1523-7060
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.ORGLETT.5C04848

P450 Biarylitide Synthase ShyB Catalyzes the Cross-Link Between His-C2 and Tyr-O4 on the Precursor Peptide

Autori: Abujunaid Habib Khan, Jabal Rahmat Haedar, Vic Kiselov, Viktors Romanuks, Gints Smits, Stefano Donadio, Chin-Soon Phan
Pubblicato in: Organic Letters, 2025, ISSN 1523-7060
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.ORGLETT.5C01487

Book chapters (1)

Marine Natural Products from Malaysia

Autori: Abujunaid Habib Khan, Chin-Soon Phan
Pubblicato in: Marine Natural Products Research in South-East Asia, 2025
Editore: Springer Nature Switzerland
DOI: 10.1007/978-3-032-01098-8_3