ERA Chair for Accelerated Synthetic Chemistry Technologies at Palacký University Olomouc

Project Information

ACCELERATOR

Grant agreement ID: 101087318

DOI

10.3030/101087318

EC signature date 14 October 2022

Start date 1 February 2023

End date 31 January 2028

Funded under

• Widening participation and spreading excellence

Total cost

€ 2 499 062,50

EU contribution

€ 2 499 062,50

Coordinated by

UNIVERZITA PALACKEHO V OLOMOUCI
Czechia

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Project website and promotional materials

Project website and promotional materials, Project newsletters

Publications

Peer reviewed articles (12)

The isocyanide SN2 reaction

Author(s): Patil Pravin Hasuram, Zheng Qiang, Kurpiewska Katarzyna, Dömling Alexander
Published in: NATURE COMMUNICATIONS, ISSN 2041-1723
Publisher: Springer Nature Group
DOI: 10.5281/ZENODO.12910732

Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors

Author(s): Ważyńska Marta A., Butera Roberto, Requesens Marta, Dömling Alexander
Published in: JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623
Publisher: ACS Publication
DOI: 10.5281/ZENODO.12821488

Balinatunfib: A Clinical Oral Small Molecule TNFα Inhibitor

Author(s): Alexander Dömling, Tad A. Holak
Published in: ChemMedChem, Issue 20, 2025, ISSN 1860-7179
Publisher: Wiley
DOI: 10.1002/CMDC.202500258

Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery

Author(s): Wang Zefeng, Shaabani Shabnam, Gao Xiang, Dömling Alexander
Published in: NATURE COMMUNICATIONS, ISSN 2041-1723
Publisher: NATURE
DOI: 10.5281/ZENODO.12909705

CBL-B – An upcoming immune-oncology target

Author(s): Riccardo Fusco, Zeinab Saedi, Imma Capriello, Andriy Lubskyy, Alexander Dömling
Published in: Expert Opinion on Therapeutic Patents, Issue 35, 2025, ISSN 1354-3776
Publisher: Informa UK Limited
DOI: 10.1080/13543776.2024.2412567

Precipitation-first synthesis and deep profiling of a 1200-member acrylamide library for covalent drug discovery

Author(s): Pravin Patil, Emis Ingenito, Riccardo Fusco, Imma Capriello, Zhirui Guan, Anuja Bhalkikar, John Gibbons, Tomas Korba, Stanislav Bashkyrtsev, Oleh Tkachenko, Alexander Dömling
Published in: Green Chemistry, Issue 27, 2025, ISSN 1463-9262
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5GC04440E

Exploring Aspartate Transcarbamoylase: A Promising Broad‐Spectrum Target for Drug Development

Author(s): Siyao Chen, Queenie Mondile, XiaoChen Du, Chao Wang, Mayur Mukim, Carsten Wrenger, Alexander S. S. Dömling, Özlem Tastan Bishop, Matthew R. Groves
Published in: ChemBioChem, Issue 26, 2025, ISSN 1439-4227
Publisher: Wiley
DOI: 10.1002/CBIC.202401009

Innovative synthesis of drug-like molecules using tetrazole as core building blocks

Author(s): Li Jingyao, Chandgude Ajay L., Zheng Qiang, Dömling Alexander
Published in: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, ISSN 1860-5397
Publisher: Beilstein-Institut
DOI: 10.5281/ZENODO.12912407

Exploring Phthalimide as the Acid Component in the Passerini Reaction

Author(s): Li Jingyao, Zheng Qiang, Dömling Alexander
Published in: ORGANIC LETTERS, ISSN 1523-7060
Publisher: ACS Publications
DOI: 10.5281/ZENODO.12911001

Multicomponent Reactions: A Promising Approach to Isotope Labeling

Author(s): Alexander Domling, Philip H. Elsinga, Siyu Xiao, Antonio Conte, Bart T. Cornelissen
Published in: Synlett, Issue 35, 2024, ISSN 0936-5214
Publisher: Georg Thieme Verlag KG
DOI: 10.1055/A-2331-6399

Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies

Author(s): Raghuwanshi Sanjeev, Zhang Xu, Arbieva Zarema, Dömling Alexander
Published in: CELL DEATH DISCOVERY, ISSN 2058-7716
Publisher: Nature
DOI: 10.5281/ZENODO.12912952

Novel Spirooxindole–Benzofuran Scaffold: Potential Inhibition Against Hepatocellular Carcinoma by Targeting MDM2‐p53 Interaction

Author(s): Muhanna K. Al‐Muhanna, Assem Barakat, Mohammad Shahidul Islam, M. Ali, Abdulmajeed Abdullah Alayyaf, Komal Zia, Zaheer Ul‐Haq, Alexander Dömling, Fardous F. El‐Senduny, Farid A. Badria
Published in: ChemistrySelect, Issue 9, 2025, ISSN 2365-6549
Publisher: Wiley
DOI: 10.1002/SLCT.202403953