Skip to main content
Go to the home page of the European Commission (opens in new window)
English English
CORDIS - EU research results
CORDIS

Proteome diversification in evolution

Objective

"Proteins are essential and incredibly versatile actors for all biological processes in living organisms. Massive amounts of data describing their amino acid sequences and 3D shapes are now openly accessible. Yet, we still know little about how they interact and function with one another in vivo. Nor how they diversified throughout evolution to orchestrate highly specialised behavioural traits. This ERC CoG proposal, PROMISE, meets the urgent need for decrypting protein sequences and structures toward guiding biological intervention. It will assess and harness the protein variations naturally occurring in multi-cellular organisms to unlock critical questions across developmental, evolutionary, and molecular biology: - What are the sites in a protein crucial for selecting its cellular partners and binding to them? How can they be modified toward modulating protein functioning?    - How did the proteomes responsible for the ability of humans and zebra finches to learn ""language"" from their peers expand in evolution? Are there convergent amino acid patterns, beyond the striking analogies in the underlying anatomical structures and in gene expression and regulation? PROMISE will leverage the tension between evolutionary divergence, gene duplication, and alternative splicing by combining massive high-throughput protein-related data integration and cutting-edge artificial intelligence techniques. It will bring a paradigm shift on assessing protein diversity and its impact on rewiring interaction networks in evolution. The expected results will provide efficient and scalable solutions to extract biological meaning from big data and transform it into interpretable and actionable models. This new knowledge will be transferable to a broad range of impactful societal issues, such as the inter-individual variability in disease susceptibility, the design of more specific drugs and more bio-compatible de novo proteins, or strategising human adaptation to climate change."

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.

You need to log in or register to use this function

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-ERC - HORIZON ERC Grants

See all projects funded under this funding scheme

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) ERC-2022-COG

See all projects funded under this call

Host institution

SORBONNE UNIVERSITE
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 952 762,50
Address
21 RUE DE L'ECOLE DE MEDECINE
75006 PARIS
France

See on map

Region
Ile-de-France Ile-de-France Paris
Activity type
Higher or Secondary Education Establishments
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 952 762,50

Beneficiaries (1)

My booklet 0 0