Proteome diversification in evolution

Project Information

PROMISE

Grant agreement ID: 101087830

DOI

10.3030/101087830

EC signature date 21 March 2023

Start date 1 September 2023

End date 31 August 2028

Funded under

• European Research Council (ERC)

Total cost

€ 1 952 762,50

EU contribution

€ 1 952 762,50

Coordinated by

SORBONNE UNIVERSITE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan

Drafting of Data Management Plan

Publications

Peer reviewed articles (9)

Navigating protein–nucleic acid sequence-structure landscapes with deep learning

Author(s): Elodie Laine, Sergei Grudinin, Roman Klypa, Isaure Chauvot de Beauchêne
Published in: Current Opinion in Structural Biology, Issue 95, 2025, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/J.SBI.2025.103162

Explaining Conformational Diversity in Protein Families through Molecular Motions

Author(s): Valentin Lombard; Sergei Grudinin; Elodie Laine
Published in: Scientific Data, Issue 11, 2024, ISSN 2052-4463
Publisher: Springer Nature
DOI: 10.1101/2024.02.06.578951

Proteome-wide prediction of the functional impact of missense variants with ProteoCast

Author(s): Marina Abakarova, Maria Inés Freiberger, Arnaud Liehrmann, Michael Rera, Elodie Laine
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-72140-1

Current Opinion in Structural Biology

Author(s): Elodie Laine; Shandar Ahmad
Published in: Current Opinion in Structural Biology, 2025, ISSN 0959-440X
Publisher: Elsevier
DOI: 10.1016/J.SBI.2025.103184

Journal of Molecular Biology

Author(s): Marina Abakarova; Maria Inés Freiberger; Arnaud Liehrmann; Michael Rera; Elodie Laine
Published in: Journal of Molecular Biology, 2026, ISSN 0022-2836
Publisher: Elsevier
DOI: 10.2139/SSRN.5688657

Proteome-wide Prediction of the Functional Impact of Missense Variants with ProteoCast

Author(s): Marina Abakarova; Maria Ines Freiberger; Arnaud Liehrmann; Michael Rera; Elodie Laine
Published in: Crossref, 2025, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.02.09.637326

SeaMoon: From protein language models to continuous structural heterogeneity

Author(s): Valentin Lombard, Dan Timsit, Sergei Grudinin, Elodie Laine
Published in: Structure, Issue 33, 2025, ISSN 0969-2126
Publisher: Elsevier BV
DOI: 10.1016/J.STR.2025.06.010

Toward a comprehensive profiling of alternative splicing proteoform structures, interactions and functions

Author(s): Elodie Laine, Maria Inés Freiberger
Published in: Current Opinion in Structural Biology, Issue 90, 2025, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/J.SBI.2024.102979

Expert-guided protein Language Models enable accurate and blazingly fast fitness prediction

Author(s): Celine Marquet; Julius Schlensok; Marina Abakarova; Burkhard Rost; Elodie Laine
Published in: Bioinformatics, Issue 40, 2024, ISSN 1367-4811
Publisher: Oxford University Press
DOI: 10.1093/BIOINFORMATICS/BTAE621

Other (1)

Data Management Plan

Conference proceedings (1)

PETIMOT: A Novel Framework for Inferring Protein Motions from Sparse Data Using SE(3)-Equivariant Graph Neural Networks

Author(s): Valentin Lombard, Sergei Grudinin, Elodie Laine
Published in: LMRL Workshop at ICLR 2025, 2025
Publisher: International Conference on Learning Representations
DOI: 10.48550/ARXIV.2504.02839