Rational and Simulation-Supported Design of Inhalable RNA Nanocarrier

Project Information

RatInhalRNA

Grant agreement ID: 101088587

DOI

10.3030/101088587

EC signature date 22 February 2023

Start date 1 April 2023

End date 31 March 2028

Funded under

• European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Molecular Dynamics Simulations Elucidate the Molecular Organization of Poly(beta-amino ester) Based Polyplexes for siRNA Delivery

Author(s): Katharina M. Steinegger; Lars Allmendinger; Sebastian Sturm; Felix Sieber-Schäfer; Adrian P. E. Kromer; Knut Müller-Caspary; Benjamin Winkeljann; Olivia M. Merkel
Published in: Nano Letters, 2024, ISSN 1526-4602
Publisher: ACS Publications
DOI: 10.1021/ACS.NANOLETT.4C04291

Molecular Dynamics Simulations Elucidate the Molecular Organization of Poly(beta-amino ester) Based Polyplexes for siRNA Delivery

Author(s): Katharina M. Steinegger, Lars Allmendinger, Sebastian Sturm, Felix Sieber-Schfer, Adrian P. E. Kromer, Knut Mller-Caspary, Benjamin Winkeljann, Olivia M. Merkel
Published in: Nano Letters, Issue 24, 2024, ISSN 1530-6984
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acs.nanolett.4c04291

Synthesis and application of spermine-based amphiphilic poly(β-amino ester)s for siRNA delivery

Author(s): Yao Jin, Friederike Adams, Anny Nguyen, Sebastian Sturm, Simone Carnerio, Knut Müller-Caspary, Olivia M. Merkel
Published in: Nanoscale Advances, Issue 5, 2023, ISSN 2516-0230
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D3NA00272A

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Author(s): Felix Sieber-Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel
Published in: Advanced Functional materials, 2025, ISSN 1616-301X
Publisher: wiley
DOI: 10.1002/ADFM.202502805

Design of Experiments Grants Mechanistic Insights into the Synthesis of Spermine-Containing PBAE Copolymers

Author(s): Adrian P. E. Kromer; Felix Sieber-Schäfer; Johan Farfan Benito; Olivia M. Merkel
Published in: ACS Applied Materials & Interfaces, 2024, ISSN 1944-8252
Publisher: ACS Publications
DOI: 10.1021/ACSAMI.4C06079

Closing the Gap between Experiment and Simulation─A Holistic Study on the Complexation of Small Interfering RNAs with Polyethylenimine

Author(s): Jonas Binder, Joshua Winkeljann, Katharina Steinegger, Lara Trnovec, Daria Orekhova, Jonas Zähringer, Andreas Hörner, Valentin Fell, Philip Tinnefeld, Benjamin Winkeljann, Wolfgang Frieß, Olivia M. Merkel
Published in: Molecular Pharmaceutics, Issue 21, 2024, ISSN 1543-8384
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACS.MOLPHARMACEUT.3C00747

Nebulization of RNA-Loaded Micelle-Embedded Polyplexes as a Potential Treatment of Idiopathic Pulmonary Fibrosis

Author(s): Joschka T. Müller, Adrian P. E. Kromer, Aysan Ezaddoustdar, Ioannis Alexopoulos, Katharina M. Steinegger, Diana Leidy Porras-Gonzalez, Otto Berninghausen, Roland Beckmann, Peter Braubach, Gerald Burgstaller, Malgorzata Wygrecka, Olivia M. Merkel
Published in: ACS Applied Materials & Interfaces, Issue 17, 2025, ISSN 1944-8244
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACSAMI.4C21657

Role of Hydrophobic Modification in Spermine-Based Poly(β-amino ester)s for siRNA Delivery and Their Spray-Dried Powders for Inhalation and Improved Storage

Author(s): Yao Jin; Xiaoxuan Wang; Adrian P.E. Kromer; Joschka T. Müller; Christoph Zimmermann; Zehua Xu; Achim Hartschuh; Friederike Adams; Olivia M. Merkel
Published in: Biomacromolecules, 2024, ISSN 1526-4602
Publisher: ACS Publications
DOI: 10.1021/ACS.BIOMAC.4C00283

Other (1)

Endosomal escape mechanisms of extracellular vesicle-based drug carriers: lessons for lipid nanoparticle design

Author(s): Lasse Hagedorn; David C. Jürgens; Olivia M. Merkel; Benjamin Winkeljann
Published in: Extracellular Vesicles and Circulating Nucleic Acids, 2024, ISSN 2767-6641
Publisher: OAE Publishing Inc.
DOI: 10.20517/EVCNA.2024.19