Rational and Simulation-Supported Design of Inhalable RNA Nanocarrier

Informazioni relative al progetto

RatInhalRNA

ID dell’accordo di sovvenzione: 101088587

DOI

10.3030/101088587

Data della firma CE 22 Febbraio 2023

Data di avvio 1 Aprile 2023

Data di completamento 31 Marzo 2028

Finanziato da

• European Research Council (ERC)

Costo totale

€ 2 000 000,00

Contributo UE

€ 2 000 000,00

Coordinato da

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (12)

Molecular Dynamics Simulations Elucidate the Molecular Organization of Poly(beta-amino ester) Based Polyplexes for siRNA Delivery

Autori: Katharina M. Steinegger; Lars Allmendinger; Sebastian Sturm; Felix Sieber-Schäfer; Adrian P. E. Kromer; Knut Müller-Caspary; Benjamin Winkeljann; Olivia M. Merkel
Pubblicato in: Nano Letters, 2024, ISSN 1526-4602
Editore: ACS Publications
DOI: 10.1021/ACS.NANOLETT.4C04291

Optimized lipid nanoparticles for pulmonary delivery of CRISPR/Cas9 targeting KRAS G12S in lung cancer

Autori: Moritz Marschhofer, Siyu Chen, Müge Molbay, Benjamin Winkeljann, Ersilia Villano, Corinne Giancaspro, Alexandra Kourou, Otto Berninghausen, Susanne Rieder, Charlotte Ungewickell, Roland Beckmann, Bastian Popper, Ana Maria Torres, Anxo Vidal, Olivia M. Merkel, Simone P. Carneiro
Pubblicato in: Journal of Controlled Release, Numero 391, 2026, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/J.JCONREL.2026.114607

Synthesis and application of spermine-based amphiphilic poly(β-amino ester)s for siRNA delivery

Autori: Yao Jin, Friederike Adams, Anny Nguyen, Sebastian Sturm, Simone Carnerio, Knut Müller-Caspary, Olivia M. Merkel
Pubblicato in: Nanoscale Advances, Numero 5, 2023, ISSN 2516-0230
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D3NA00272A

Understanding excipient interactions unlocks untapped potential of RNA-lipid nanoparticles in dry powder formulations for local pulmonary delivery

Autori: Nora Martini, Leonie Deßloch, Taras Sych, Otto Berninghausen, J. Merl-Pham, Sjoerd Dijkstra, Simone P. Carneiro, Marion Frankenberger, Roland Beckmann, Jürgen Behr, Gabriele Matschiner, Christine Schuberth-Wagner, A. Önder Yildirim, David C. Jürgens, Erdinc Sezgin, Olivia M. Merkel, Benjamin Winkeljann
Pubblicato in: Journal of Controlled Release, Numero 390, 2026, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/J.JCONREL.2025.114539

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Autori: Felix Sieber-Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel
Pubblicato in: Advanced Functional materials, 2025, ISSN 1616-301X
Editore: wiley
DOI: 10.1002/ADFM.202502805

Design of Experiments Grants Mechanistic Insights into the Synthesis of Spermine-Containing PBAE Copolymers

Autori: Adrian P. E. Kromer; Felix Sieber-Schäfer; Johan Farfan Benito; Olivia M. Merkel
Pubblicato in: ACS Applied Materials & Interfaces, 2024, ISSN 1944-8252
Editore: ACS Publications
DOI: 10.1021/ACSAMI.4C06079

Closing the Gap between Experiment and Simulation─A Holistic Study on the Complexation of Small Interfering RNAs with Polyethylenimine

Autori: Jonas Binder, Joshua Winkeljann, Katharina Steinegger, Lara Trnovec, Daria Orekhova, Jonas Zähringer, Andreas Hörner, Valentin Fell, Philip Tinnefeld, Benjamin Winkeljann, Wolfgang Frieß, Olivia M. Merkel
Pubblicato in: Molecular Pharmaceutics, Numero 21, 2024, ISSN 1543-8384
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.MOLPHARMACEUT.3C00747

Nebulization of RNA-Loaded Micelle-Embedded Polyplexes as a Potential Treatment of Idiopathic Pulmonary Fibrosis

Autori: Joschka T. Müller, Adrian P. E. Kromer, Aysan Ezaddoustdar, Ioannis Alexopoulos, Katharina M. Steinegger, Diana Leidy Porras-Gonzalez, Otto Berninghausen, Roland Beckmann, Peter Braubach, Gerald Burgstaller, Malgorzata Wygrecka, Olivia M. Merkel
Pubblicato in: ACS Applied Materials & Interfaces, Numero 17, 2025, ISSN 1944-8244
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACSAMI.4C21657

Role of Hydrophobic Modification in Spermine-Based Poly(β-amino ester)s for siRNA Delivery and Their Spray-Dried Powders for Inhalation and Improved Storage

Autori: Yao Jin; Xiaoxuan Wang; Adrian P.E. Kromer; Joschka T. Müller; Christoph Zimmermann; Zehua Xu; Achim Hartschuh; Friederike Adams; Olivia M. Merkel
Pubblicato in: Biomacromolecules, 2024, ISSN 1526-4602
Editore: ACS Publications
DOI: 10.1021/ACS.BIOMAC.4C00283

A hybrid polymeric system for pulmonary mRNA delivery: Advancing mucosal vaccine development

Autori: Min Jiang, Felix Sieber-Schäfer, Simone P. Carneiro, Dana Matzek, Anny Nguyen, Diana Leidy Porras-Gonzalez, Arun Kumar Verma, Miriam Kolog-Gulko, David C. Jürgens, Gerald Burgstaller, Bastian Popper, Xun Sun, Olivia M. Merkel
Pubblicato in: Cell Biomaterials, Numero 2, 2026, ISSN 3050-5623
Editore: Elsevier BV
DOI: 10.1016/J.CELBIO.2025.100311

From Bits to Bonds: High-Throughput Virtual Screening of Ribonucleic Acid Nanocarriers Using a Combinatorial Approach of Machine Learning and Molecular Dynamics

Autori: Felix Sieber-Schäfer, Jonas Binder, Tim Münchrath, Katharina M. Steinegger, Min Jiang, Benjamin Winkeljann, Wolfgang Friess, Olivia M. Merkel
Pubblicato in: Journal of the American Chemical Society, Numero 147, 2025, ISSN 0002-7863
Editore: American Chemical Society (ACS)
DOI: 10.1021/JACS.5C12694

QbD product development: rapid optimization and scale-up of PBAE-based siRNA delivery <i>via</i> DoE-guided microfluidics

Autori: Adrian P. E. Kromer, Laetitia J. M. Eller, David C. Jürgens, Olivia M. Merkel
Pubblicato in: RSC Pharmaceutics, 2026, ISSN 2976-8713
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5PM00379B

Other (1)

Endosomal escape mechanisms of extracellular vesicle-based drug carriers: lessons for lipid nanoparticle design

Autori: Lasse Hagedorn; David C. Jürgens; Olivia M. Merkel; Benjamin Winkeljann
Pubblicato in: Extracellular Vesicles and Circulating Nucleic Acids, 2024, ISSN 2767-6641
Editore: OAE Publishing Inc.
DOI: 10.20517/EVCNA.2024.19