Rational and Simulation-Supported Design of Inhalable RNA Nanocarrier

Informazioni relative al progetto

RatInhalRNA

ID dell’accordo di sovvenzione: 101088587

DOI

10.3030/101088587

Data della firma CE 22 Febbraio 2023

Data di avvio 1 Aprile 2023

Data di completamento 31 Marzo 2028

Finanziato da

• European Research Council (ERC)

Costo totale

€ 2 000 000,00

Contributo UE

€ 2 000 000,00

Coordinato da

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (8)

Molecular Dynamics Simulations Elucidate the Molecular Organization of Poly(beta-amino ester) Based Polyplexes for siRNA Delivery

Autori: Katharina M. Steinegger; Lars Allmendinger; Sebastian Sturm; Felix Sieber-Schäfer; Adrian P. E. Kromer; Knut Müller-Caspary; Benjamin Winkeljann; Olivia M. Merkel
Pubblicato in: Nano Letters, 2024, ISSN 1526-4602
Editore: ACS Publications
DOI: 10.1021/ACS.NANOLETT.4C04291

Molecular Dynamics Simulations Elucidate the Molecular Organization of Poly(beta-amino ester) Based Polyplexes for siRNA Delivery

Autori: Katharina M. Steinegger, Lars Allmendinger, Sebastian Sturm, Felix Sieber-Schfer, Adrian P. E. Kromer, Knut Mller-Caspary, Benjamin Winkeljann, Olivia M. Merkel
Pubblicato in: Nano Letters, Numero 24, 2024, ISSN 1530-6984
Editore: American Chemical Society (ACS)
DOI: 10.1021/acs.nanolett.4c04291

Synthesis and application of spermine-based amphiphilic poly(β-amino ester)s for siRNA delivery

Autori: Yao Jin, Friederike Adams, Anny Nguyen, Sebastian Sturm, Simone Carnerio, Knut Müller-Caspary, Olivia M. Merkel
Pubblicato in: Nanoscale Advances, Numero 5, 2023, ISSN 2516-0230
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D3NA00272A

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Autori: Felix Sieber-Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel
Pubblicato in: Advanced Functional materials, 2025, ISSN 1616-301X
Editore: wiley
DOI: 10.1002/ADFM.202502805

Design of Experiments Grants Mechanistic Insights into the Synthesis of Spermine-Containing PBAE Copolymers

Autori: Adrian P. E. Kromer; Felix Sieber-Schäfer; Johan Farfan Benito; Olivia M. Merkel
Pubblicato in: ACS Applied Materials & Interfaces, 2024, ISSN 1944-8252
Editore: ACS Publications
DOI: 10.1021/ACSAMI.4C06079

Closing the Gap between Experiment and Simulation─A Holistic Study on the Complexation of Small Interfering RNAs with Polyethylenimine

Autori: Jonas Binder, Joshua Winkeljann, Katharina Steinegger, Lara Trnovec, Daria Orekhova, Jonas Zähringer, Andreas Hörner, Valentin Fell, Philip Tinnefeld, Benjamin Winkeljann, Wolfgang Frieß, Olivia M. Merkel
Pubblicato in: Molecular Pharmaceutics, Numero 21, 2024, ISSN 1543-8384
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.MOLPHARMACEUT.3C00747

Nebulization of RNA-Loaded Micelle-Embedded Polyplexes as a Potential Treatment of Idiopathic Pulmonary Fibrosis

Autori: Joschka T. Müller, Adrian P. E. Kromer, Aysan Ezaddoustdar, Ioannis Alexopoulos, Katharina M. Steinegger, Diana Leidy Porras-Gonzalez, Otto Berninghausen, Roland Beckmann, Peter Braubach, Gerald Burgstaller, Malgorzata Wygrecka, Olivia M. Merkel
Pubblicato in: ACS Applied Materials & Interfaces, Numero 17, 2025, ISSN 1944-8244
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACSAMI.4C21657

Role of Hydrophobic Modification in Spermine-Based Poly(β-amino ester)s for siRNA Delivery and Their Spray-Dried Powders for Inhalation and Improved Storage

Autori: Yao Jin; Xiaoxuan Wang; Adrian P.E. Kromer; Joschka T. Müller; Christoph Zimmermann; Zehua Xu; Achim Hartschuh; Friederike Adams; Olivia M. Merkel
Pubblicato in: Biomacromolecules, 2024, ISSN 1526-4602
Editore: ACS Publications
DOI: 10.1021/ACS.BIOMAC.4C00283

Other (1)

Endosomal escape mechanisms of extracellular vesicle-based drug carriers: lessons for lipid nanoparticle design

Autori: Lasse Hagedorn; David C. Jürgens; Olivia M. Merkel; Benjamin Winkeljann
Pubblicato in: Extracellular Vesicles and Circulating Nucleic Acids, 2024, ISSN 2767-6641
Editore: OAE Publishing Inc.
DOI: 10.20517/EVCNA.2024.19