Project description DEENESFRITPL Real-time bioreactor sensing system Bioreactors are large vessels that support the culture of cells under controlled conditions and are used for the production of biologic pharmaceuticals in industry. Maintaining a contamination-free environment is fundamental for the sustainable and competitive production of bioproducts. The EU-funded LIBRA project aims to introduce a novel multi-sensing technology that allows screening of nutrients and pathogens in bioreactor samples in real time. The LIBRA system is chip-based, modular and automatable, and can be accommodated to a variety of existing devices to monitor cultivation processes. Implementation of the system will considerably advance bioreactor-based processes and lead to safer products. Show the project objective Hide the project objective Objective The bioreactor industry is currently flourishing with a global market valued estimated at 2.3 B€ in 2020 and predicted to exceed 6.6 B€ euro by 2030, growing at a rate of 10.7% CAGR. Despite this impressive growth, there are challenges which can significantly impede the further advancement of bioreactors: Bioproducts can be sustainable and competitive only if reliable and contamination-free production is ensured. Currently, there is no catholic solution to this issue. To this end, LIBRA project introduces a benchtop smart multi-sensing system for the in-line automatable screening of cultivation processes in bioreactors. The LIBRA sensing technology lies in the use of light based integrated on-chip, real time sensors. A novel integration procedure of the photonic platforms together with disposable microfluidic modules and biofunctionalization units will result in a modular system with interchangeable components enabling the screening of nutrients and pathogens in bioreactor samples, according to the end users need. Furthermore, the LIBRA system will be able to be attached and integrated to various bioreactor systems regardless of their form factors, spanning from stirred tank bioreactors to single use bioreactors (SUB). To achieve this, LIBRA will rely on a highly multi-disciplinary consortium comprising expertise and specialization in several fields spanning photonics, surface functionalization, microfluidics, advanced packaging and assembly, artificial intelligence and bioreactor manufacturers. The exploitable results of LIBRA are expected to disrupt the current PIC-based sensing landscape, as estimated by the two business cases stemming from the project: the market revenues one year after the end of this project are expected to be €7.8 million growing to almost €59 million in 2032, and plethora of new IP and new business opportunities for the partners involved in the joint venture of LIBRA. Fields of science natural sciencescomputer and information sciencesartificial intelligencenatural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsengineering and technologyenvironmental biotechnologybioremediationbioreactorsengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsengineering and technologyindustrial biotechnologybiomaterials Keywords Photonics based modules fast multisensing system microfluidic module interchangeable modules pathogens detection nutrients screening bioreactor manufacturing Programme(s) HORIZON.2.4 - Digital, Industry and Space Main Programme HORIZON.2.4.2 - Key Digital Technologies Topic(s) HORIZON-CL4-2022-DIGITAL-EMERGING-01-03 - Advanced multi-sensing systems (Photonics Partnership) (RIA) Call for proposal HORIZON-CL4-2022-DIGITAL-EMERGING-01 See other projects for this call Funding Scheme HORIZON-RIA - HORIZON Research and Innovation Actions Coordinator ETHNICON METSOVION POLYTECHNION Net EU contribution € 686 250,00 Address HEROON POLYTECHNIOU 9 ZOGRAPHOU CAMPUS 157 80 ATHINA Greece See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 686 250,00 Participants (10) Sort alphabetically Sort by Net EU contribution Expand all Collapse all LIONIX INTERNATIONAL BV Netherlands Net EU contribution € 790 750,00 Address HENGELOSESTRAAT 500 7521 AN Enschede See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Oost-Nederland Overijssel Twente Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 790 750,00 OPTAGON FOTONIKI IDIOTIKI KEFALAIOUCHIKI ETAIRIA Greece Net EU contribution € 259 375,00 Address EL. VENIZELOU 47 15351 Pallini, Athina See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Αττική Aττική Ανατολική Αττική Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 259 375,00 FIBO LABS OY Finland Net EU contribution € 570 000,00 Address HUDSSON CAPELLANKUJA 1 AS 9 00580 Helsinki See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 570 000,00 DEMCON LIFE SCIENCES & HEALTH ENSCHEDE BV Netherlands Net EU contribution € 602 805,00 Address INSTITUTENWEG 25 7521 PH Enschede See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Oost-Nederland Overijssel Twente Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 705 150,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. DEMCON FOCAL BV Netherlands Net EU contribution € 102 345,00 Address INSTITUTENWEG 25 A 7521 PH Enschede See on map Region Oost-Nederland Overijssel Twente Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 102 345,00 PHOSPRINT IDIOTIKI KEFALAIOUXIKIETAIREIA Greece Net EU contribution € 433 750,00 Address Patriarchou Grigoriou E’ & Neapoleos 27, Lefkippos Technology Park, NCSRD 153 41 AGIA PARASKEVI ATHINA See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Αττική Aττική Βόρειος Τομέας Αθηνών Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 433 750,00 CONSIGLIO NAZIONALE DELLE RICERCHE Italy Net EU contribution € 252 750,00 Address PIAZZALE ALDO MORO 7 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 252 750,00 SCINUS CELL EXPANSION NETHERLANDS B.V. Netherlands Net EU contribution € 297 500,00 Address PROFESSOR BRONKHORSTLAAN 10, BUILDING 48 3723 MB Bilthoven See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region West-Nederland Utrecht Utrecht Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 297 500,00 AARHUS UNIVERSITET Denmark Net EU contribution € 261 250,00 Address NORDRE RINGGADE 1 8000 Aarhus C See on map Region Danmark Midtjylland Østjylland Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 261 250,00 ECOVAMED France Net EU contribution € 173 750,00 Address 13 BIS, RUE DU PAVE DES GARDES 92370 Chaville See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ile-de-France Ile-de-France Hauts-de-Seine Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 173 750,00 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT Switzerland Net EU contribution € 0,00 Address RUE JAQUET DROZ 1 2000 Neuchatel See on map Region Schweiz/Suisse/Svizzera Espace Mittelland Neuchâtel Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data
