Descrizione del progetto
Sistema di rilevamento del bioreattore in tempo reale
I bioreattori sono grandi recipienti che offrono un supporto per la coltura di cellule in condizioni controllate e sono utilizzati per la produzione di farmaci biologici nell’industria. Il mantenimento di un ambiente privo di contaminazioni è fondamentale per la produzione sostenibile e competitiva di bioprodotti. Il progetto LIBRA, finanziato dall’UE, si propone di introdurre una nuova tecnologia multisensoriale che consenta lo screening di sostanze nutritive e agenti patogeni in campioni di bioreattore in tempo reale. Il sistema LIBRA è basato su chip, modulare e automatizzabile e può essere adattato a svariati dispositivi esistenti per monitorare i processi di coltivazione. L’implementazione del sistema farà compiere grandi progressi ai processi basati su bioreattori e porterà a prodotti più sicuri.
Obiettivo
The bioreactor industry is currently flourishing with a global market valued estimated at 2.3 B€ in 2020 and predicted to exceed 6.6 B€ euro by 2030, growing at a rate of 10.7% CAGR. Despite this impressive growth, there are challenges which can significantly impede the further advancement of bioreactors: Bioproducts can be sustainable and competitive only if reliable and contamination-free production is ensured. Currently, there is no catholic solution to this issue. To this end, LIBRA project introduces a benchtop smart multi-sensing system for the in-line automatable screening of cultivation processes in bioreactors. The LIBRA sensing technology lies in the use of light based integrated on-chip, real time sensors. A novel integration procedure of the photonic platforms together with disposable microfluidic modules and biofunctionalization units will result in a modular system with interchangeable components enabling the screening of nutrients and pathogens in bioreactor samples, according to the end users need. Furthermore, the LIBRA system will be able to be attached and integrated to various bioreactor systems regardless of their form factors, spanning from stirred tank bioreactors to single use bioreactors (SUB). To achieve this, LIBRA will rely on a highly multi-disciplinary consortium comprising expertise and specialization in several fields spanning photonics, surface functionalization, microfluidics, advanced packaging and assembly, artificial intelligence and bioreactor manufacturers. The exploitable results of LIBRA are expected to disrupt the current PIC-based sensing landscape, as estimated by the two business cases stemming from the project: the market revenues one year after the end of this project are expected to be €7.8 million growing to almost €59 million in 2032, and plethora of new IP and new business opportunities for the partners involved in the joint venture of LIBRA.
Campo scientifico
- natural sciencescomputer and information sciencesartificial intelligence
- natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidics
- engineering and technologyenvironmental biotechnologybioremediationbioreactors
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
- engineering and technologyindustrial biotechnologybiomaterials
Parole chiave
Programma(i)
Argomento(i)
Invito a presentare proposte
HORIZON-CL4-2022-DIGITAL-EMERGING-01
Vedi altri progetti per questo bandoMeccanismo di finanziamento
HORIZON-RIA - HORIZON Research and Innovation ActionsCoordinatore
157 80 ATHINA
Grecia