Deciphering cellular signalling to cure graft-versus-host disease (GVHD) and leukemia relapse

Project Information

AlloCure

Grant agreement ID: 101094168

DOI

10.3030/101094168

EC signature date 19 June 2023

Start date 1 October 2023

End date 30 September 2028

Funded under

• European Research Council (ERC)

Total cost

€ 2 498 945,00

EU contribution

€ 2 498 943,00

Coordinated by

UNIVERSITAETSKLINIKUM FREIBURG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

Journal of Experimental Medicine

Author(s): Chatterjee S, Rückert T, Martin I, Michaeli E, Buescher J, Apostolova P, Erny D, Lalioti ME, Biavasco F, Hartmann A, Runge S, Braun LM, Talvard-Balland N, Adams RC, Schmitt-Graeff A, Cook J, Wenger V, Athanassopoulos D, Hasavci D, Vallejo-Janeta AP, Blank
Published in: J Exp Med., 2025, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/JEM.20242180

Protocol to study phagocytosis of apoptotic murine splenocytes by syngeneic antigen-presenting cells in vitro

Author(s): Lukas M. Braun, Robert Zeiser
Published in: STAR Protocols, Issue 6, 2025, ISSN 2666-1667
Publisher: Elsevier BV
DOI: 10.1016/J.XPRO.2025.103903

Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment

Author(s): Dominik Schmidt, Cornelia Endres, Rouven Hoefflin, Geoffroy Andrieux, Melissa Zwick, Nikolaos Karantzelis, Hans F. Staehle, Janaki Manoja Vinnakota, Sandra Duquesne, Miriam Mozaffari Jovein, Dietmar Pfeifer, Heiko Becker, Bruce R. Blazar, Alexander Zähringer, Justus Duyster, Tilman Brummer, Melanie Boerries, Julian Baumeister, Khalid Shoumariyeh, Juan Li, Anthony R. Green, Florian H. Heidel, Itay Tirosh, Heike L. Pahl, Nils Leimkühler, Natalie Köhler, Marcelo A.S. de Toledo, Steffen Koschmieder, Robert Zeiser
Published in: Cancer Research, Issue 84, 2024, ISSN 0008-5472
Publisher: American Association for Cancer Research (AACR)
DOI: 10.1158/0008-5472.CAN-23-3553

Protocol to study in vivo organ-specific migration of apoptotic splenocytes in mice with tumor and immune checkpoint inhibitor-induced colitis

Author(s): Lukas M. Braun, Robert Zeiser
Published in: STAR Protocols, Issue 6, 2025, ISSN 2666-1667
Publisher: Elsevier BV
DOI: 10.1016/J.XPRO.2025.103878

FLT3-ITD Induces CMTM6 and Enhances Immune Escape in Acute Myeloid Leukemia

Author(s): Melissa Zwick, Bastian Zinkel, Corinna Spohr, Tamina Rückert, Sebastian Halbach, Khalid Shoumariyeh, Jonas Scheid, Anna-Sophia Baur, Lukas M. Braun, Moritz Angel, Elisa Michaeli, Abhijeet Todkar, Annika Nelde, Melanie Märklin, Samuel J. Holzmayer, Severin Dicks, Melanie Boerries, Sandra Duquesne, Alexandra Emilia Schlaak, Patricia Otto-Mora, Bertram Bengsch, Marcel Schiff, Sandra Kissel, Michael Selle, Marie Follo, Heidi Altmann, Desiree Kunadt, Anna-Lena Illert, Juliane S. Walz, Gerd Walz, Justus Duyster, Johannes Schetelig, Tilman Brummer, Robert Zeiser, Natalie Köhler
Published in: Cancer Research, 2025, ISSN 0008-5472
Publisher: American Association for Cancer Research (AACR)
DOI: 10.1158/0008-5472.CAN-25-0349

Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells

Author(s): Zhen Zhang, Marlene Langenbach, Sagar Sagar, Viktor Fetsch, Jonas Stritzker, Elizabeth Severa, Ke Meng, Frances Winkler, Nisha Rana, Katharina Zoldan, Ira Godbole, Sabrina Solis, Jeffrey S. Weber, David Rafei-Shamsabadi, Saskia Lehr, Rebecca Diehl, Ana Cecilia Venhoff, Reinhard E. Voll, Nico Buettner, Christoph Neumann-Haefelin, Tobias Boettler, Maike Hofmann, Melanie Boerries, Frank Meiss, Robert Zeiser, Robert Thimme, Ramin S. Herati, Bertram Bengsch
Published in: Nature Immunology, 2024, ISSN 1529-2908
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41590-024-02027-0

Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity

Author(s): Lukas M. Braun, Sophie Giesler, Geoffroy Andrieux, Roxane Riemer, Nana Talvard-Balland, Sandra Duquesne, Tamina Rückert, Susanne Unger, Stefanie Kreutmair, Melissa Zwick, Marie Follo, Alina Hartmann, Natascha Osswald, Wolfgang Melchinger, Stefanie Chapman, James A. Hutchinson, Sebastian Haferkamp, Leopold Torster, Julian Kött, Christoffer Gebhardt, Dirk Hellwig, Nikolaos Karantzelis, Till Wallrabenstein, Theresa Lowinus, Mehtap Yücel, Niklas Brehm, Justyna Rawluk, Dietmar Pfeifer, Peter Bronsert, Manuel Rogg, Sven Mattern, Mathias Heikenwälder, Stefano Fusco, Nisar P. Malek, Stephan Singer, Annette Schmitt-Graeff, Fatih Ceteci, Florian R. Greten, Bruce R. Blazar, Melanie Boerries, Natalie Köhler, Justus Duyster, Gabriele Ihorst, Silke Lassmann, Philip Keye, Susana Minguet, Dirk Schadendorf, Selma Ugurel, David Rafei-Shamsabadi, Robert Thimme, Peter Hasselblatt, Bertram Bengsch, Christoph Schell, Erika L. Pearce, Frank Meiss, Burkhard Becher, Carolin Funke-Lorenz, Jan-Malte Placke, Petya Apostolova, Robert Zeiser
Published in: Cancer Cell, Issue 43, 2025, ISSN 1535-6108
Publisher: Elsevier BV
DOI: 10.1016/J.CCELL.2025.01.004