Project description
Cardiovascular disease prevention through an immunological blueprint
Epidemiological evidence suggests an association between chronic inflammation and risk for cardiovascular disease (CVD). Understanding the mechanistic link between the two can help develop prevention strategies that lower inflammation while maintaining a healthy immune system. To achieve this, the EU-funded CARE-IN-HEALTH project proposes to integrate omics and clinical data from a large network of collaborators into an AI-based decision support system. The goal is to provide individual signatures for patients, which will serve as the basis for the resolution of inflammation. Given that millions of individuals suffer and die from CVD, the CARE-IN-HEALTH system is expected to prevent transition to CVD and support a healthy life.
Objective
With 1.9 million deaths and an economic burden estimated to €200 billion each year in Europe, cardiovascular diseases (CVD) represent a significant public health problem with clear unmet needs in terms of prevention. Chronic inflammation is a critical residual risk for the health to CVD transition with limited possibilities to stop it without causing immunosuppression. To tackle this issue, CARE-IN-HEALTH propose to identify the resolution of inflammation to develop new prevention strategies to lower inflammation with a retained immune defence against infections to sustainably stay healthy. As chronic inflammation and CVD are driven and regulated by lipids, an interdisciplinary consortium of highly experienced centres has been assembled to collect, integrate, and exploit epidemiological, multi-omics and immune data to be translated into the CARE-IN-HEALTH ATLAS, which will be provided openly accessible for the scientific community and health care professionals. Such knowledge base will not only allow to systematically identify and validate an individual’s critical immune pathways through AI-empowered models and clinical translation but most importantly will provide tools for drawing a personalized blueprint on how to build a unique model for each citizen’s resolution of inflammation. To apply these findings, a digital CARE-IN-HEALTH MCDSS (multi-criteria decision support system), will be developed to guide health care professional to design personalized CVD prevention strategies. To further extend project’s findings and empower citizens, a CARE-IN-HEALTH BIOSENSOR point-of-care will be constructed to monitor resolution of inflammation. By evaluating these tools in real life settings through two proof-of-concept clinical trials, CARE-IN-HEALTH aims to propose a true paradigm shift for the public health needs on how to stay staying healthy in a rapidly changing society by promoting resolution of inflammation.
Fields of science
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensors
- medical and health scienceshealth sciencespublic health
- natural sciencesbiological sciencesbiochemistrybiomoleculeslipids
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
Keywords
Programme(s)
Funding Scheme
HORIZON-RIA - HORIZON Research and Innovation ActionsCoordinator
75654 Paris
France