Projektbeschreibung
Herz-Kreislauf-Erkrankungen durch immunologischen Bauplan vorbeugen
Epidemiologische Beweise deuten auf einen Zusammenhang zwischen chronischer Entzündung und dem Risiko einer Herz-Kreislauf-Erkrankung hin. Das Verständnis der mechanistischen Verbindung zwischen beiden Faktoren kann dazu beitragen, Präventionsstrategien zu entwickeln, die Entzündungen entschärfen und gleichzeitig das Immunsystem gesund erhalten. Zu diesem Zweck schlägt das EU-finanzierte Projekt CARE-IN-HEALTH vor, Omik-Daten und klinische Daten aus einem großen Netzwerk von Mitwirkenden in ein KI-basiertes Entscheidungsunterstützungssystem zu integrieren. Das Ziel lautet, individuelle Signaturen für Betroffene bereitzustellen, die als Grundlage für das Abklingen von Entzündungen dienen. Angesichts der Tatsache, dass Millionen Menschen an Herz-Kreislauf-Erkrankungen leiden und an ihnen sterben, ist zu erwarten, dass das CARE-IN-HEALTH-System den Ausbruch von Herz-Kreislauf-Erkrankungen verhindert und ein gesundes Leben unterstützt.
Ziel
With 1.9 million deaths and an economic burden estimated to €200 billion each year in Europe, cardiovascular diseases (CVD) represent a significant public health problem with clear unmet needs in terms of prevention. Chronic inflammation is a critical residual risk for the health to CVD transition with limited possibilities to stop it without causing immunosuppression. To tackle this issue, CARE-IN-HEALTH propose to identify the resolution of inflammation to develop new prevention strategies to lower inflammation with a retained immune defence against infections to sustainably stay healthy. As chronic inflammation and CVD are driven and regulated by lipids, an interdisciplinary consortium of highly experienced centres has been assembled to collect, integrate, and exploit epidemiological, multi-omics and immune data to be translated into the CARE-IN-HEALTH ATLAS, which will be provided openly accessible for the scientific community and health care professionals. Such knowledge base will not only allow to systematically identify and validate an individual’s critical immune pathways through AI-empowered models and clinical translation but most importantly will provide tools for drawing a personalized blueprint on how to build a unique model for each citizen’s resolution of inflammation. To apply these findings, a digital CARE-IN-HEALTH MCDSS (multi-criteria decision support system), will be developed to guide health care professional to design personalized CVD prevention strategies. To further extend project’s findings and empower citizens, a CARE-IN-HEALTH BIOSENSOR point-of-care will be constructed to monitor resolution of inflammation. By evaluating these tools in real life settings through two proof-of-concept clinical trials, CARE-IN-HEALTH aims to propose a true paradigm shift for the public health needs on how to stay staying healthy in a rapidly changing society by promoting resolution of inflammation.
Wissenschaftliches Gebiet
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensors
- medical and health scienceshealth sciencespublic health
- natural sciencesbiological sciencesbiochemistrybiomoleculeslipids
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
Schlüsselbegriffe
Programm/Programme
Thema/Themen
Aufforderung zur Vorschlagseinreichung
Andere Projekte für diesen Aufruf anzeigenFinanzierungsplan
HORIZON-RIA - HORIZON Research and Innovation ActionsKoordinator
75654 Paris
Frankreich