Project description
Treatment outcome biomarkers for immune diseases
In many immune-mediated diseases such as Crohn’s disease and rheumatoid arthritis the immune system requires suppression. This is where biological therapy comes in, such as the administration of therapeutic antibodies targeting inflammatory proteins or blocking the activity/trafficking of immune cells. However, treatment success is variable and there are no biomarkers capable of predicting clinical response, causing unnecessary suffering to patients and high healthcare costs. The EU-funded METHYLOMIC project focuses on epigenetics as a means of predicting the outcome of biological therapies. Researchers will introduce and validate DNA methylation biomarkers as accurate predictors of response to therapy.
Objective
Monoclonal antibodies have become a mainstay of therapy in common immune-mediated diseases (IMID) including Crohn’s disease (CD), rheumatoid arthritis (RA), and psoriasis (PsO). Current therapeutics include antibodies (“biologicals”) targeting inflammatory proteins such as Tumor Necrosis Factor (adalimumab), leukocyte trafficking (vedolizumab), or IL-12/IL-23 (ustekinumab). At present however, it cannot be predicted which biological will be effective in an individual patient, with only <40% of patients showing primary response to any given therapeutic. Treatment failure is associated with disease complications, and increased health care costs.. Hence the overwhelming need for predictive biomarkers to guide personalised medicine in IMID is evident. No biomarker to target therapy is validated in clinical practice.
In METHYLOMIC, we build on multiple previous cohort studies in which we confirmed epigenetic biomarkers (specifically DNA methylation) as the most stringent predictor of response to biological therapy, zooming in on CD. Specifically, we discovered and validated differential DNA methylation profiles in peripheral blood as biomarkers of response/deep remission for 3 approved biologicals in CD. Through the use of machine learning algorithms, treatment response could be predicted with up to 93% accuracy for each biological for CD, and RA.
METHYLOMICS is committed to bringing personalised treatment-selection in CD and other IMID to clinical practice. We have teamed up clinical, epigenetic, and DNA diagnostics experts, patient organisations, and companies across Europe, for further validation studies, develop a marketable rapid targeted methylation assay that we than validate in a unique prospective randomised clinical trial for CD. Efficiency and cost-effectiveness is assessed in great detail and regulatory approval is guided by experts to assure delivery of the first epigenetic kit personalised treatment of CD.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine rheumatology
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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HORIZON.2.1.5 - Tools, Technologies and Digital Solutions for Health and Care, including personalised medicine
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-RIA - HORIZON Research and Innovation Actions
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-HLTH-2022-TOOL-11
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1081 HV Amsterdam
Netherlands
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Participants (13)
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1101 BV Amsterdam
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1930 Zaventem
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20132 Milano
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6720 Szeged
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1000 Ljubljana
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9000 GENT
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1649-035 LISBOA
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3584 CM Utrecht
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2645LT Delfgauw
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08014 Barcelona
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
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1081 HV Amsterdam
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1000 Bruxelles / Brussel
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3645WG Vinkeveen
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Partners (4)
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Participation ended
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4102 Seraing
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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94080 South San Francisco
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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OX1 2JD Oxford
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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WC2R 2LS London
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