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CANCER PREVENTION VS CANCER TREATMENT: THE RARE TUMOUR RISK SYNDROMES BATTLE

Project description

Surveillance strategy for the prevention of rare tumour risk syndromes

Rare tumour risk syndromes (RTRS) are rare diseases with a very high risk of cancer development caused by heritable genetic variants. Undiagnosed RTRS patients develop particularly aggressive cancers, leading to premature death. RTRS cancers are preventable in the case of surveillance of asymptomatic RTRS patients and the application of the early intervention. The objectives of the EU-funded PREVENTABLE project include merging clinical knowledge on RTRS pathways of care and the real-life RTRS patients’ clinical data and experiences with health economic models and social sciences approach. The project will highlight the cost-benefit of risk-reduction interventions in RTRS and provide guidelines for better communication among clinical teams and RTRS patients.

Objective

Rare tumour risk syndromes (RTRS) are rare diseases, affecting 5 per 10.000 people or less and caused by heritable genetic variants. In RTRS, the lifetime risk to develop various cancers can be as high as 100%, and patients have a 50% chance of transmitting the disease to their offspring. When undiagnosed or not surveilled, many asymptomatic RTRS patients develop particularly aggressive cancers, leading to premature death, severely impacting theirs and their families’ health and wellbeing. Cancers in RTRS can be prevented and survival rates maximized if asymptomatic RTRS patients are intensively surveilled for RTRS-prone organs, cancer-prone organs are surgically removed prior to disease development, or very small cancerous or pre-cancerous lesions are removed or treated. RTRS are therefore a unique and tangible context for cancer prevention, early diagnosis and treatment with curative intent. However, risk-reduction strategies are not always prioritized in genetically diagnosed and asymptomatic RTRS patients, and most healthcare systems keep on opting for treatment of clinically expressed cancer. This occurs despite the knowledge that hospitalization has the highest weight on advanced cancer healthcare spending. It is therefore urgent to demonstrate the cost-benefit of the application of preventive measures in RTRS syndromes.
The ambition of the PREVENTABLE project is to merge specialized clinical knowledge on RTRS pathways of care, real-life clinical data from RTRS patients and experiences from professionals and patients, with health economic models and social sciences approaches to estimate the cost-benefit of risk-reduction interventions in RTRS and delineate guidelines for its communication among and within clinical teams and RTRS patients. PREVENTABLE project results will be delivered to a diversity of stakeholders, including policy-makers, in order to promote the implementation of cost-effective RTRS patient-centered care in Europe.

Coordinator

I3S - INSTITUTO DE INVESTIGACAO E INOVACAO EM SAUDE DA UNIVERSIDADE DO PORTO
Net EU contribution
€ 1 660 005,00
Address
RUA ALFREDO ALLEN 208
4200-135 Porto
Portugal

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Region
Continente Norte Área Metropolitana do Porto
Activity type
Research Organisations
Links
Total cost
€ 2 065 602,25

Participants (13)

Partners (1)