Unveiling the functional outcome of single nucleotide polymorphisms and variants in oligodendroglia in multiple sclerosis

Project Information

SingleMS

Grant agreement ID: 101096064

DOI

10.3030/101096064

EC signature date 23 November 2023

Start date 1 January 2024

End date 31 December 2028

Funded under

• European Research Council (ERC)

Total cost

€ 3 182 846,00

EU contribution

€ 3 182 846,00

Coordinated by

KAROLINSKA INSTITUTET
Sweden

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (4)

Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis

Author(s): Chao Zheng, Bastien Hervé, Mandy Meijer, Leslie Ann Rubio Rodríguez-Kirby, André Ortlieb Guerreiro Cacais, Petra Kukanja, Mukund Kabbe, Tony Jimenez-Beristain, Tomas Olsson, Eneritz Agirre, Gonçalo Castelo-Branco
Published in: Nature Neuroscience, Issue 28, 2025, ISSN 1097-6256
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41593-025-02100-3

Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis

Author(s): Olivia G. Thomas, Urszula Rykaczewska, Marina Galešić, Rianne T.M. van der Burgt, Nils Hallén, Filippo Ferro, Mattias Bronge, Zoe Marti, Yue Li, Alexandra Hill Riqué, Jianing Lin, Aleksa Krstic, Alicja Gromadzka, András Levente Szonder, Chiara Sorini, María Reina-Campos, Ting Sun, Leslie A. Rubio Rodríguez-Kirby, Özge Dumral, Rasmus Berglund, Majid Pahlevan Kakhki, Milena Z. Adzemovic, Manuel Zeitelhofer, Birce Akpinar, Katarina Tengvall, Ola B. Nilsson, Erik Holmgren, Chiara Starvaggi Cucuzza, Klara Asplund Högelin, Guro Gafvelin, Katharina Fink, Gonçalo Castelo-Branco, Maria Needhamsen, Mohsen Khademi, Fredrik Piehl, Torbjörn Gräslund, Lars Alfredsson, Harald Lund, Per Uhlén, Ingrid Kockum, Roland Martin, Maja Jagodic, Hans Grönlund, André Ortlieb Guerreiro-Cacais, Tomas Olsson
Published in: Cell, Issue 189, 2026, ISSN 0092-8674
Publisher: Elsevier BV
DOI: 10.1016/J.CELL.2025.12.032

Disease-associated oligodendroglia: a putative nexus in neurodegeneration

Author(s): Gonçalo Castelo-Branco, Petra Kukanja, André O. Guerreiro-Cacais, Leslie A. Rubio Rodríguez-Kirby
Published in: Trends in Immunology, Issue 45, 2024, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/J.IT.2024.08.003

Spatial dynamics of brain development and neuroinflammation

Author(s): Di Zhang, Leslie A. Rubio Rodríguez-Kirby, Yingxin Lin, Wenqi Wang, Mengyi Song, Li Wang, Lijun Wang, Shigeaki Kanatani, Tony Jimenez-Beristain, Yonglong Dang, Mei Zhong, Petra Kukanja, Shuozhen Bao, Shaohui Wang, Xinyi Lisa Chen, Fu Gao, Dejiang Wang, Hang Xu, Cong Ma, Xing Lou, Yang Liu, Jinmiao Chen, Nenad Sestan, Per Uhlén, Arnold Kriegstein, Hongyu Zhao, Gonçalo Castelo-Branco, Rong Fan
Published in: Nature, Issue 647, 2025, ISSN 0028-0836
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41586-025-09663-Y