Project description DEENESFRITPL Genome and environment in alcohol-related liver cancer Chronic alcohol consumption leads to alcohol-related liver disease (ALD), the most common cause of liver cirrhosis, hepatocellular carcinoma (HCC) and liver-related deaths in Europe. Patients with advanced alcohol-related hepatocellular carcinoma (ALD-HCC) have a poor prognosis, underscoring the importance of prevention and early detection. The EU-funded GENIAL project aims to identify genetic and environmental determinants in ALD-HCC onset. Researchers will investigate the mechanism by which specific genetic and environmental factors may promote liver carcinogenesis and how they increase the risk of individuals. By combining clinical, genomics and digital imaging data using AI, the consortium hopes to generate a predictive approach that can facilitate disease detection at an early stage. Show the project objective Hide the project objective Objective Alcohol-related hepatocellular carcinoma (ALD-HCC) is, in Europe, the leading cause of liver cancer (2nd most common cause of cancer-related death worldwide, affecting both men and women). ALD-HCC has a median 5-year survival rate of 15%. Yet, the prognosis is driven by the tumour stage, with curative options providing a 5-year survival exceeding 70% for early-stage HCC (<20% of cases). Therefore, interventions aiming to improve prevention and early detection are key. ALD-HCC results from the interplay between environmental determinants and genetic variations. A comprehensive characterisation of environmental factors (e.g. diet, lifestyle) linked to ALD-HCC is still lacking. We recently performed the 1st genome-wide association study of ALD-HCC and identified predisposing genetic variations. However, their role on alcohol-related liver carcinogenesis needs clarification and the genetic architecture of ALD-HCC remains mostly unknown. GENIAL brings together partners with unique expertise in clinical hepatology, single-cell and spatial multi-omics, artificial intelligence (AI) and communication and dissemination capacities. Our aim is to 1) portray genetic and environmental determinants promoting ALD-HCC; 2) evaluate how they interact at cellular level in human samples and preclinical models to get novel insights into liver carcinogenesis, and identify chemopreventive targets; and 3) assess how these determinants modulate the ALD-HCC risk in prospective cohorts of patients included in HCC surveillance programs. Environmental factors will be comprehensively characterised in an ongoing clinical trial designed to evaluate alternative methods for early-stage HCC detection. Finally, AI models, reaching the minimal viable product stage by the end of GENIAL, will be used to integrate genetic and non-genetic information (including digital imaging) to develop novel cost-effective strategies towards prevention and early-stage detection of ALD-HCC in at-risk individuals.This action is part of the Cancer Mission cluster of projects on ‘‘Understanding’. Fields of science natural sciencescomputer and information sciencesartificial intelligencemedical and health sciencesclinical medicineoncologyliver cancernatural sciencesbiological sciencescell biologycell metabolismmedical and health sciencesclinical medicinehepatology Keywords Liver cancer Environmental determinants Genetic epidemiology Programme(s) HORIZON.2.1 - Health Main Programme Topic(s) HORIZON-MISS-2021-CANCER-02-03 - Better understanding of the impact of risk factors and health determinants on the development and progression of cancer Call for proposal HORIZON-MISS-2021-CANCER-02 See other projects for this call Funding Scheme RIA - Research and Innovation action Coordinator UNIVERSITE LIBRE DE BRUXELLES Net EU contribution € 866 338,00 Address Avenue franklin roosevelt 50 1050 Bruxelles / brussel Belgium See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (12) Sort alphabetically Sort by Net EU contribution Expand all Collapse all VIB VZW Belgium Net EU contribution € 417 218,75 Address Rijvisschestraat 120 9052 Zwijnaarde - gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EUROPEAN LIVER PATIENTS ASSOCIATION Belgium Net EU contribution € 83 375,00 Address Place du champs de mars 5 1050 Bruxelles / brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France Net EU contribution € 2 613 757,50 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ASSISTANCE PUBLIQUE HOPITAUX DE PARIS France Net EU contribution € 2 209 425,00 Address 55 boulevard diderot 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITE PARIS 13 France Net EU contribution € 393 845,00 Address Avenue jean-baptiste clement 99 93430 Villetaneuse See on map Region Ile-de-France Ile-de-France Seine-Saint-Denis Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD Portugal Net EU contribution € 1 500 937,50 Address Avenida brasilia, centro de investigacao da fundacao champalimaud 1400-038 Lisboa See on map Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITA DEGLI STUDI DI MILANO Italy Net EU contribution € 494 094,37 Address Via festa del perdono 7 20122 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,01 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO Italy Net EU contribution € 195 536,88 Address Via francesco sforza 28 20122 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 TECHNISCHE UNIVERSITAET DRESDEN Germany Net EU contribution € 1 534 875,00 Address Helmholtzstrasse 10 01069 Dresden See on map Region Sachsen Dresden Dresden, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 StratiPath AB Sweden Net EU contribution € 667 975,00 Address Igelbacken 25 170 62 Solna See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITE PARIS CITE France Net EU contribution € 605 000,00 Address 85 bd saint germain 75006 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FINOVATIS France Net EU contribution € 414 375,00 Address 62 rue de bonnel 69003 Lyon See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all EUROPEAN ASSOCIATION FOR THE STUDYOF THE LIVER Switzerland Net EU contribution € 0,00 Address Rue daubin 7 1203 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding No data