Understanding Gene ENvironment Interaction in ALcohol-related hepatocellular carcinoma

Project Information

GENIAL

Grant agreement ID: 101096312

DOI

10.3030/101096312

EC signature date 28 November 2022

Start date 1 January 2023

End date 31 December 2027

Funded under

• Health

Total cost

€ 11 996 753,01

EU contribution

€ 11 996 753,00

Coordinated by

UNIVERSITE LIBRE DE BRUXELLES
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Other (2)

D4.22 - Common video and/or a common cluster brochure

Common video and/or a common cluster brochure (cluster 'Understanding')

D4.16 - Conferences participation

Dissemination through participation at our partners' (ELPA/EASL) conferences. Side meetings may be organised in EASL conferences notably to improve visibility of the partners, if so required

Documents, reports (6)

D5.22 - Policy Brief

Policy brief formulating recommendations based on the research and innovation strand of the ‘Understanding’ annual cluster meeting

D4.11 - Educational materials

Materials for training led by TUD, USPN and ELPA (1 training session by USPN, 2 trainings by ELPA, 1 summer school by TUD during the whole project).First annual exchange program led by ULB.

D5.17 - Conclusions of common annual meeting of the ‘Understanding’ cluster

Conclusions of common annual meeting of the ‘Understanding’ cluster

D5.14 - Common work plan for scientific collaboration under the ‘Understanding’ cluster

Common work plan for scientific collaboration under the ‘Understanding’ cluster

D5.18 - Conclusions of common annual meeting of the ‘Understanding’ cluster

Conclusions of common annual meeting of the ‘Understanding’ cluster

D4.3 - Dissemination of ongoing work

Create an GENIAL network with social media presence, deliver patient focus groups, and prepare patient-focused literature.Coordinate the communication departments of partner universities to prepare conferences.

Websites, patent fillings, videos etc. (2)

D4.7 - Annual newsletters

Plan and release a simple and accessible newsletter to update both patients and interested parties on project aims.

D4.1 - GENIAL Website + logo

Project specific website and project logo to regularly disseminate up to date information on the project to all stakeholders.

Publications

Peer reviewed articles (20)

Germline mutations and somatic mosaicism in steatotic liver diseases and related liver carcinogenesis

Author(s): Eric Trépo, Jessica Zucman-Rossi, Jean-Charles Nault
Published in: Nature Reviews Gastroenterology & Hepatology, 2026, ISSN 1759-5045
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41575-026-01175-Y

Associations between fruit and vegetable consumption and HCC occurrence in patients with cirrhosis

Author(s): Florian Manneville, Zineb Zouakia, Séverine Donneger, Leopold K. Fezeu, Alice Bellicha, Pierre Nahon, Mathilde Touvier, Nathalie Ganne-Carrié, Chantal Julia
Published in: JHEP Reports, Issue 7, 2025, ISSN 2589-5559
Publisher: Elsevier BV
DOI: 10.1016/J.JHEPR.2025.101355

Human genetics of steatotic liver disease: insights into insulin resistance and lipid metabolism

Author(s): Rosellina M. Mancina, Luca Valenti, Stefano Romeo
Published in: Nature Metabolism, Issue 7, 2025, ISSN 2522-5812
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S42255-025-01394-8

Neuro‐ILC Interactions in Host Physiology and Defence

Author(s): Cristina Godinho‐Silva, Miguel Rendas, Henrique Veiga‐Fernandes
Published in: European Journal of Immunology, Issue 55, 2025, ISSN 0014-2980
Publisher: Wiley
DOI: 10.1002/EJI.70037

Prevalence and Determinants of Liver Disease in Relatives of Italian Patients With Advanced MASLD

Author(s): Serena Pelusi, Luisa Ronzoni, Jessica Rondena, Chiara Rosso, Grazia Pennisi, Paola Dongiovanni, Sara Margarita, Rossana Carpani, Giorgio Soardo, Daniele Prati, Annalisa Cespiati, Salvatore Petta, Elisabetta Bugianesi, Luca Valenti
Published in: Clinical Gastroenterology and Hepatology, Issue 22, 2024, ISSN 1542-3565
Publisher: Elsevier BV
DOI: 10.1016/J.CGH.2023.12.033

The “A-B-C” Classification Reveals Outcome Trajectories in Patients With Hepatocellular Carcinoma Under Atezolizumab/Bevacizumab

Author(s): Claudia Campani, Clelia Galvanin, Ju Hyun Shim, Mohamed Bouattour, Yann Touchefeu, Victoria Delhoume, Olivier Rosmorduc, Alina Pascale, Jihyun An, Han Chu Lee, Helene Regnault, Dominique Thabut, Valérie Paradis, Julien Calderaro, Marianne Ziol, Aurélie Beaufrère, Alexandre Sayadi, Giuliana Amaddeo, Manon Allaire, Isabelle Olivier-Hourmand, Chloe Metivier, Elena Rondini, Maxime Ronot, Line Ntandja-Wandji, Violaine Ozenne, Sabrina Sidali, Fabio Marra, Clémence Hollande, Nathalie Ganne-Carrié, Pierre Nahon, Marie Lequoy, Rohini Sharma, Massih Ningarahi, Eric Trépo, Jean-Charles Nault
Published in: Clinical Gastroenterology and Hepatology, 2026, ISSN 1542-3565
Publisher: Elsevier BV
DOI: 10.1016/J.CGH.2025.11.018

Nature Communications

Author(s): Omar S. M. El Nahhas; Chiara M. L. Loeffler; Zunamys I. Carrero; Marko van Treeck; Fiona R. Kolbinger; Katherine J. Hewitt; Hannah S. Muti; Mara Graziani; Qinghe Zeng; Julien Calderaro; Nadina Ortiz-Brüchle; Tanwei Yuan; Michael Hoffmeister; Hermann Brenner; Alexander Brobeil; Jorge S. Reis-Filho; Jakob Nikolas Kather
Published in: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024), 2024, ISSN 2041-1723
Publisher: Nature Communications
DOI: 10.48550/arxiv.2304.05153

Interplay among lipoprotein(a), hepatic and vascular damage in individuals with metabolic dysfunction

Author(s): Serena Pelusi, Chiara Macchi, Francesco Malvestiti, Sara Margarita, Irene De Matteis, Giulia Periti, Jessica Rondena, Stefania Mira, Francesca Iemma, Martina Tranchina, Barbara Nardi, Carla Lucci, Cesare R. Sirtori, Oscar Millet, Jose M. Mato, Giovanni Targher, Daniele Prati, Massimiliano Ruscica, Luca Valenti, null null, Serena Pelusi, Giulia Periti, Vittoria Moretti, Stefania Mira, Sara Margarita, Luisa Ronzoni, Daniele Marchelli, Hadi Heidgah Torgabehei, Alessandra Cazzaniga, Elena Sinopoli, Laura Cerami, Elia Casirati, Eniada Rrapaj, Divya Akkaldev, Francesco Malvestiti, Martina Tranchina, Francesca Ferrari, Giuseppe Lamorte, Valentina Vaira, Daniele Prati, Luca Valenti, Roberta D’Ambrosio, Giulia Tosetti, Massimo Iavarone Pietro Lampertico, Marco Maggioni, Emanuela Orsi, Annalisa Cespiati, Paola Dongiovanni, Anna Ludovica Fracanzani, Chiara Rosso, Angelo Armandi, Gian Paolo Caviglia, Elisabetta Bugianesi, Grazia Pennisi, Salvatore Petta, Antonio Liguori, Luca Miele, Giorgio Soardo, Francesco Paolo Russo, Alessandro Federico, Federica Tavaglione, Umberto Vespasiani-Gentilucci, Francesca Marchignoli, Loris Pironi, Teresa Pollicino
Published in: Cardiovascular Diabetology, Issue 24, 2025, ISSN 1475-2840
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12933-025-03004-Z

Bringing genetic testing into the clinical management of people with MASLD: Are we there yet?

Author(s): Luca Valenti, Hannes Hagström
Published in: Journal of Hepatology, Issue 83, 2025, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/J.JHEP.2025.05.016

Focus on Semaglutide 2.4 mg/week for the Treatment of Metabolic Dysfunction‐Associated Steatohepatitis

Author(s): Salvatore Petta, KyeongJin Kim, Giovanni Targher, Stefano Romeo, Silvia Sookoian, Ming‐Hua Zheng, Alessio Aghemo, Luca Valenti
Published in: Liver International, Issue 45, 2025, ISSN 1478-3223
Publisher: Wiley
DOI: 10.1111/LIV.70407

Neuroepithelial VIP–VIPR1 interactions differentially control enteric type 1 and type 2 immunity

Author(s): Roksana M. Pirzgalska, Beatriz Henriques-Alves, Bruno Raposo, Eric de Sousa, Júlio Torres, Jaechan Ryu, Cristina Godinho-Silva, Miguel Rendas, Madalena Pereira, Inês Godinho, Hélder Ribeiro, Vasco Correia, Manuel O. Jakob, Patrycja M. Forster, Christoph Wilhelm, Christoph S. N. Klose, Ricardo Rio-Tinto, Verena M. Link, Tânia Carvalho, Carlos M. Minutti, Manuela Ferreira, Henrique Veiga-Fernandes
Published in: Nature Immunology, Issue 26, 2025, ISSN 1529-2908
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41590-025-02326-0

Value of non-invasive test dynamics in guiding HCC surveillance decisions after HCV cure in patients with cirrhosis

Author(s): Pierre Nahon, Clovis Lusivika-Nzinga, Philippe Merle, Fabien Zoulim, Thomas Decaens, Nathalie Ganne-Carrié, Georges-Philippe Pageaux, Vincent Leroy, Laurent Alric, Jean-Pierre Bronowicki, Marc Bourlière, Jérôme Gournay, Albert Tran, Stanislas Pol, Philippe Mathurin, Véronique Loustaud-Ratti, Sophie Métivier, Victor De Ledinghen, Armand Abergel, Dominique Thabut, Louis D’Alteroche, Mohammed Bouattour, Tarik Asselah, Denis Ouzan, Paul Cales, Olivier Chazouillères, Moana Gelu-Simeon, Dominique Roulot, Jérôme Boursier, Carole Cagnot, Sonia Tamazirt, Alina Pascale, Samuel Nilusmas, Maïté Lewin, Marianne Ziol, Fabrice Carrat, Jean-Charles Duclos-Vallée
Published in: Journal of Hepatology, Issue 83, 2025, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/J.JHEP.2025.02.008

High Fat and Sugar Diet Increases Enteric cDC1 and Oral Antigen‐Specific Tregs

Author(s): K. Fischer, O. Horno, B. Raposo, I. Godinho, H. Ribeiro, H. Veiga-Fernandes, M. Martínez-López
Published in: Journal of Immunology Research, Issue 2025, 2025, ISSN 2314-8861
Publisher: Wiley
DOI: 10.1155/JIMR/6600076

Predictors of controlled attenuation parameter in metabolic dysfunction

Author(s): Cristiana Bianco; Serena Pelusi; Sara Margarita; Federica Tavaglione; Oveis Jamialahmadi; Francesco Malvestiti; Giulia Periti; Jessica Rondena; Melissa Tomasi; Rossana Carpani; Luisa Ronzoni; Matteo Vidali; Ferruccio Ceriotti; Mirella Fraquelli; Umberto Vespasiani‐Gentilucci; Stefano Romeo; Daniele Prati; Luca Valenti
Published in: Crossref, 2023, ISSN 2050-6414
Publisher: UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
DOI: 10.1002/ueg2.12513

Differences between hepatocellular carcinoma caused by alcohol and other aetiologies

Author(s): Nathalie Ganne-Carrié, Pierre Nahon
Published in: Journal of Hepatology, Issue 82, 2025, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/J.JHEP.2024.12.030

Impact of clonal hematopoiesis of indeterminate potential on hepatocellular carcinoma in individuals with steatotic liver disease

Author(s): Alfredo Marchetti, Serena Pelusi, Alessio Marella, Francesco Malvestiti, Antony Ricchiuti, Luisa Ronzoni, Marta Lionetti, Vittoria Moretti, Elisabetta Bugianesi, Luca Miele, Umberto Vespasiani-Gentilucci, Paola Dongiovanni, Alessandro Federico, Giorgio Soardo, Roberta D’Ambrosio, Misti V. McCain, Helen L. Reeves, Vincenzo La Mura, Daniele Prati, Niccolò Bolli, Luca Valenti, null null
Published in: Hepatology, Issue 80, 2024, ISSN 0270-9139
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HEP.0000000000000839

Enteric nervous system-derived VIP restrains differentiation of LGR5+ stem cells toward the secretory lineage impeding type 2 immune programs

Author(s): Manuel O. Jakob, Nele Sterczyk, Sotiria Boulekou, Patrycja M. Forster, Luisa Barleben, Nadra Alzain, Katja J. Jarick, Roksana M. Pirzgalska, Bruno Raposo, Karl Hansson, Elisabeth E. L. Nyström, Aurelia Gondrand, Miguel González-Acera, Pierre S. Leclère, Marlen S. Lapson, Sarah Poggenseier, Divija Deshpande, Laura Velleman, Tilman Breiderhoff, Max Felix Brunkhorst, Anton M. Schüle, Gabriela M. Guerra, Pawel Durek, Mir-Farzin Mashreghi, Anja A. Kühl, Coco Chu, Christoph Schneider, Carl Weidinger, Britta Siegmund, Thierry M. Nordmann, David Voehringer, Jay V. Patankar, Christoph Becker, George M. H. Birchenough, Henrique Veiga-Fernandes, Francesca Ronchi, Marina Kolesnichenko, Andreas Diefenbach, Christoph S. N. Klose
Published in: Nature Immunology, Issue 26, 2025, ISSN 1529-2908
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41590-025-02325-1

Fifteen Years of <scp>PNPLA3</scp> : Transforming Hepatology Through Human Genetics

Author(s): Stefano Romeo, Luca Valenti
Published in: Liver International, Issue 45, 2025, ISSN 1478-3223
Publisher: Wiley
DOI: 10.1111/LIV.70240

Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis

Author(s): Marko Šestan, Bruno Raposo, Miguel Rendas, David Brea, Roksana Pirzgalska, Ana Rasteiro, Maria Aliseychik, Inês Godinho, Hélder Ribeiro, Tania Carvalho, Stephan Wueest, Daniel Konrad, Henrique Veiga-Fernandes
Published in: Science, Issue 387, 2025, ISSN 0036-8075
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIENCE.ADI3624

Scientific Reports

Author(s): Firas Khader; Gustav Müller-Franzes; Soroosh Tayebi Arasteh; Tianyu Han; Christoph Haarburger; Maximilian Schulze-Hagen; Philipp Schad; Sandy Engelhardt; Bettina Baeßler; Sebastian Foersch; Johannes Stegmaier; Christiane Kuhl; Sven Nebelung; Jakob Nikolas Kather; Daniel Truhn
Published in: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023), 2023, ISSN 2045-2322
Publisher: Nature
DOI: 10.18154/rwth-2023-05893

Intellectual Property Rights

Patent (1)

METHOD FOR HEPATOCELLULAR CARCINOMA RISK STRATIFICATION

Application/Publication number: 20 23077913
Date: 2023-10-09
Applicant(s): ASSISTANCE PUBLIQUE HOPITAUX DE PARIS