Objective
The bacterial pathogen Staphylococcus aureus is currently the second most common cause of death associated with antibiotic resistant infections. The most useful antibiotics in clinical use have multiple targets, as compounds against single proteins rapidly succumb to the capacity of bacteria to develop resistance. To think innovatively about antibiotic discovery, we need to think not only about individual cellular processes, but also about how they are interconnected and coordinated, so that we can devise methods to strike bacterial cells, simultaneously, in multiple pathways.
The bacterial cell cycle consists of a series of coordinated events required for bacterial growth, during which cells duplicate their mass and undergo chromosome replication and segregation, assembly of the division machinery, cytokinesis, and cell separation to generate two new daughter cells. Unregulated cell cycle progression may have lethal consequences for the cell and therefore bacteria have evolved various mechanisms for the precise spatiotemporal control of main cell cycle events. Some important checkpoints have been studied, particularly the link between chromosome replication/segregation and septum synthesis, to avoid DNA breaks. However, the mechanisms for coordination of other cell cycle events are still unknown. What triggers initiation of peptidoglycan synthesis, the target of beta-lactam antibiotics, after assembly of the division machinery? How does the cell coordinate synthesis of the membrane and peptidoglycan, the two major cell surface components, during cell division? What prevents premature septum splitting, which would expose an immature cell surface, devoid of virulence factors, leading to pathogen elimination by the innate immune system of an infected host?
The aim of this project is to find the missing links between major cell cycle events, while also developing assays useful for antibiotic discovery.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences genetics DNA
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- natural sciences biological sciences genetics chromosomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1099 085 Lisboa
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.