Stabilization of Protein Protein Interactions; transforming molecular glue discovery from art into science

Project Information

PPI-Glue

Grant agreement ID: 101098234

DOI

10.3030/101098234

EC signature date 24 May 2023

Start date 1 September 2023

End date 31 August 2028

Funded under

• European Research Council (ERC)

Total cost

€ 2 496 596,00

EU contribution

€ 2 496 596,00

Coordinated by

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (18)

Site-specific molecular glues for the 14-3-3/Tau pS214 protein–protein interaction <i>via</i> reversible covalent imine tethering

Author(s): Ansgar Oberheide, Maxime C. M. van den Oetelaar, Jakob J. A. Scheele, Jan Borggräfe, Semmy F. H. Engelen, Michael Sattler, Christian Ottmann, Peter J. Cossar, Luc Brunsveld
Published in: RSC Medicinal Chemistry, Issue 16, 2025, ISSN 2632-8682
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4MD00833B

Automated navigation of condensate phase behavior with active machine learning

Author(s): Yannick H. A. Leurs, Willem van den Hout, Andrea Gardin, Joost L. J. van Dongen, Andoni Rodriguez-Abetxuko, Nadia A. Erkamp, Jan C. M. van Hest, Francesca Grisoni, Luc Brunsveld
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-64617-2

Journal of the American Chemical Society

Author(s): Thijs W. van Veldhuisen; Renske M. J. Dijkstra; Auke A. Koops; Peter J. Cossar; Jan C. M. van Hest; Luc Brunsveld
Published in: Journal of the American Chemical Society, 2025, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/JACS.4C17567

Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation

Author(s): Janine Hochmair; Maxime C. M. van den Oetelaar; Leandre Ravatt; Lisa Diez; Lenne J. M. Lemmens; Renata Ponce-Lina; Rithika Sankar; Maximilian Franck; Gesa Nolte; Ekaterina Semenova; Satabdee Mohapatra
Published in: Communications Biology, 2024, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/S42003-025-08548-0

Proximity-enhanced cysteine–histidine crosslinking for elucidating intrinsically disordered and other protein complexes

Author(s): Qi Wu, Sebastian A. H. van den Wildenberg, Jeroen C. R. Brzoskowski, Maxime C. M. van den Oetelaar, Carlo J. A. Verhoef, Sylvia A. A. M. Genet, Christian Ottmann, Albert J. Markvoort, Luc Brunsveld, Peter J. Cossar
Published in: Chemical Science, Issue 16, 2025, ISSN 2041-6520
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4SC07419J

Modulation of Protein–Protein Interactions with Molecular Glues in a Synthetic Condensate Platform

Author(s): Thijs W. van Veldhuisen, Renske M. J. Dijkstra, Auke A. Koops, Peter J. Cossar, Jan C. M. van Hest, Luc Brunsveld
Published in: Journal of the American Chemical Society, Issue 147, 2025, ISSN 0002-7863
Publisher: American Chemical Society (ACS)
DOI: 10.1021/JACS.4C17567

Macrocyclic Molecular Glues for the 14‐3‐3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship

Author(s): Marloes A. M. Pennings, Merel A. W. van den Bosch, Ansgar Oberheide, Carlo J. A. Verhoef, Christian Ottmann, Albert J. Markvoort, Galen P. Miley, Luc Brunsveld
Published in: Angewandte Chemie International Edition, Issue 65, 2026, ISSN 1433-7851
Publisher: Wiley
DOI: 10.1002/ANIE.202521678

ChemBioChem

Author(s): Qi Wu; Federica Centorrino; Xavier Guillory; Madita Wolter; Christian Ottmann; Peter J. Cossar; Luc Brunsveld
Published in: ChemBioChem, 2023, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/CBIC.202300636

Journal of the American Chemical Society

Author(s): Yannick H. A. Leurs; Sanne N. Giezen; Yudong Li; Willem van den Hout; Jay Beeren; Linn J. M. van den Aker; Ilja K. Voets; Jan C. M. van Hest; Luc Brunsveld
Published in: Journal of the American Chemical Society, 2025, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/JACS.5C03740

Chemical Science

Author(s): Qi Wu; Sebastian A. H. van den Wildenberg; Jeroen C. R. Brzoskowski; Maxime C. M. van den Oetelaar; Carlo J. A. Verhoef; Sylvia A. A. M. Genet; Christian Ottmann; Albert J. Markvoort; Luc Brunsveld; P
Published in: Chemical Science, 2025, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/D4SC07419J

Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex

Author(s): Markella Konstantinidou, Marios Zingiridis, Marloes A. M. Pennings, Michael Fragkiadakis, Johanna M. Virta, Jezrael L. Revalde, Emira J. Visser, Christian Ottmann, Luc Brunsveld, Constantinos G. Neochoritis, Michelle R. Arkin
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61176-4

Nature Communications

Author(s): Liora S. Katz; Emira J. Visser; Kathrin F. Plitzko; Marloes A. M. Pennings; Peter J. Cossar; Isabelle L. Tse; Markus Kaiser; Luc Brunsveld; Christian Ottmann; Donald K. Scott
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1101/2024.02.16.580675

Spatiotemporal Control Over Protein Release from Artificial Cells via a Light‐Activatable Protease

Author(s): Arjan Hazegh Nikroo, Wiggert J. Altenburg, Thijs W. van Veldhuisen, Luc Brunsveld, Jan C. M. van Hest
Published in: Advanced Biology, Issue 9, 2025, ISSN 2701-0198
Publisher: Wiley
DOI: 10.1002/ADBI.202400353

Identifying 14-3-3 interactome binding sites with deep learning

Author(s): Laura van Weesep; Rıza Özçelik; Marloes Pennings; Emanuele Criscuolo; Christian Ottmann; Luc Brunsveld; Francesca Grisoni
Published in: Digital Discovery, 2025, ISSN 2635-098X
Publisher: Royal Society of Chemistry
DOI: 10.26434/CHEMRXIV-2025-18TN6

Site-specific molecular glues for the 14-3-3/Tau pS214 protein–protein interaction <i>via</i> reversible covalent imine tethering

Author(s): Ansgar Oberheide; Maxime C. M. van den Oetelaar; Jakob J. A. Scheele; Jan Borggräfe; Semmy F. H. Engelen; Michael Sattler; Christian Ottmann; Peter J. Cossar; Luc Brunsveld
Published in: RSC Medicinal Chemistry, 2025, ISSN 2632-8682
Publisher: Royal Society of Chemistry
DOI: 10.1039/D4MD00833B

Discovery of 14-3-3 PPI Stabilizers by Extension of an Amidine-Substituted Thiophene Fragment

Author(s): Qi Wu, Federica Centorrino, Xavier Guillory, Madita Wolter, Christian Ottmann, Peter J. Cossar, Luc Brunsveld
Published in: ChemBioChem, 2024, ISSN 1439-7633
Publisher: Chemistry Europe
DOI: 10.1002/CBIC.202300636

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

Author(s): Liora S. Katz, Emira J. Visser, Kathrin F. Plitzko, Marloes A. M. Pennings, Peter J. Cossar, Isabelle L. Tse, Markus Kaiser, Luc Brunsveld, Christian Ottmann, Donald K. Scott
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-57241-7

Stabilization of Condensate Interfaces Using Dynamic Protein Insertion

Author(s): Yannick H. A. Leurs, Sanne N. Giezen, Yudong Li, Willem van den Hout, Jay Beeren, Linn J. M. van den Aker, Ilja K. Voets, Jan C. M. van Hest, Luc Brunsveld
Published in: Journal of the American Chemical Society, Issue 147, 2025, ISSN 0002-7863
Publisher: American Chemical Society (ACS)
DOI: 10.1021/JACS.5C03740