Descripción del proyecto
Un modelo de gemelo biológico digital del cerebro humano cambiará la medicina de precisión
Los modelos de gemelos biológicos digitales del cerebro humano consisten en una tecnología de vanguardia cuyo objetivo es crear un modelo celular miniaturizado del cerebro de una persona mediante una combinación de tecnología de células madre y análisis avanzado de la actividad de las redes neuronales. En el proyecto 3D-BrAIn, financiado por el Consejo Europeo de Innovación y dirigido por un consorcio de científicos, se creará un modelo de gemelo biológico digital del cerebro humano que será personalizado, preciso y predictivo. Su objetivo principal es revolucionar la medicina de precisión personalizada para los trastornos del sistema nervioso central. En concreto, el equipo del proyecto combinará tres tecnologías pioneras: una novedosa tecnología de modelización del cerebro humano mediante cultivos de organoides corticales en 3D, una tecnología puntera de conjuntos de múltiples electrodos en 3D para registros electrofisiológicos de alta resolución y unos algoritmos automatizados de aprendizaje automático a medida para analizar grandes conjuntos de datos.
Objetivo
The long-term vision of the 3D-BrAIn consortium is to revolutionize personalized precision medicine for central nervous system (CNS)
disorders, by developing an innovative bio-digital twin model of the human brain that is personalized, precise, and predictive.
In this pathfinder project we bring together three breakthrough technologies: 1) a novel, highly reproducible human brain modelling
technology using robust adherent iPSC-derived 3D cortical organoid cultures, 2) a unique, state-of-the-art 3D multi-electrode array
(MEA) technology for non-invasive high-resolution electrophysiological recordings and 3) a novel approach to analyse and interpret
the large quantities of functional data using tailored automated machine learning (ML)-based algorithms.
With this breakthrough approach we overcome significant hurdles that made it thus far impossible to create a truly representative
and functional model of the CNS for personalized medicine, drug screening and neurotoxicity testing. The revolutionary 3D-BrAIn
high-precision CNS platform will allow robust and accurate modelling of the CNS for a broad range of neuropsychiatric diseases.
Ultimately, the 3D-BrAIn technology will be translatable to multiple other organ systems (cardiomyocytes, pancreatic islets, retina), to
non-invasively obtain longitudinal 3D high-resolution electrophysiological recordings and effectively interpret them.
In this project a prototype of the 3D-BrAIn platform will be developed by growing functional 3D organoids that faithfully resemble
the human cortex on 3D MEA micropillar electrodes, enabling continuous functional monitoring and by developing ML-based
algorithms that can process and interpret the large spatiotemporal data sets. Once all individual components are optimized and
integrated, proof-of-concept will be obtained by validating the platform for two of the envisaged applications: CNS drug
development and neurotoxicity screening.
Ámbito científico
- natural sciencesbiological sciencesneurobiology
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health sciencesclinical medicineophthalmology
- medical and health scienceshealth sciencespersonalized medicine
- natural sciencescomputer and information sciencesartificial intelligencemachine learning
Palabras clave
Programa(s)
- HORIZON.3.1 - The European Innovation Council (EIC) Main Programme
Convocatoria de propuestas
HORIZON-EIC-2022-PATHFINDEROPEN-01
Consulte otros proyectos de esta convocatoriaRégimen de financiación
HORIZON-EIC - HORIZON EIC GrantsCoordinador
3015 GD Rotterdam
Países Bajos