Objective BIOACTION aims at developing a new methodology in implant technology based on functionalized bio-hydrogels that will convert the negative occurrence of biofilm-associated infections, the primary cause of implant infections and failure, into a positive resource. The main goal of BIOACTION is to transform implant-associated bacteria for the programmable production of specific proteins for in vivo cell recruitment and tissue regeneration, exploiting gene sequences loaded on engineered liposomes and phages, bound to hydrogel scaffolds. BIOACTION will develop new biomimetic substrates that can transform biofilm into extracellular matrix for the regeneration of target tissues. It will establish a high versatile technology to be used as injectable materials and implant coatings for periodontal and peri-implant infection treatments. The proposed approach will be validated in two clinically relevant animal models: dental implant and permanent transcutaneous bone.BIOACTION, would radically advance the future of infection treatment by revolutionizing the classical approaches leading to the improvement of state of care, health outcomes and to achieve huge socio-economic benefits. The project isstrongly interdisciplinary in nature involving expertise biomaterials, synthetic biology, phage and liposome technology, medicine.As a results, this innovative approach will bring the research and knowledge far beyond the current state-of-the-art and will lead, through the planned validation, as proof-of-concept of new materials and technique with a broader application in regenerative medicine. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologynatural sciencesbiological sciencessynthetic biologynatural sciencesbiological sciencesmicrobiologyvirologyengineering and technologyindustrial biotechnologybiomaterialsmedical and health sciencesmedical biotechnologyimplants Keywords Bio-hydrogels Bactofection Liposome Phages Hard tissue regeneration Processing technologies Programme(s) HORIZON.3.1 - The European Innovation Council (EIC) Main Programme Topic(s) HORIZON-EIC-2022-PATHFINDEROPEN-01-01 - EIC Pathfinder Open 2022 Call for proposal HORIZON-EIC-2022-PATHFINDEROPEN-01 See other projects for this call Funding Scheme HORIZON-EIC - HORIZON EIC Grants Coordinator CONSIGLIO NAZIONALE DELLE RICERCHE Net EU contribution € 807 500,00 Address Piazzale aldo moro 7 00185 Roma Italy See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (5) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO Italy Net EU contribution € 493 750,00 Address Duomo 6 13100 Vercelli See on map Region Nord-Ovest Piemonte Vercelli Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITE DE LIEGE Belgium Net EU contribution € 618 000,00 Address Place du 20 aout 7 4000 Liege See on map Region Région wallonne Prov. Liège Arr. Liège Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA Spain Net EU contribution € 352 112,50 Address Carrer baldiri reixac planta 2a 10-12 08028 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FERENTIS Lithuania Net EU contribution € 412 500,00 Address Savanoriu 231 02300 Vilnius See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Lietuva Sostinės regionas Vilniaus apskritis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 IN SRL IMPRESA SOCIALE Italy Net EU contribution € 220 000,00 Address Via carducci 9a 33100 Udine See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nord-Est Friuli-Venezia Giulia Udine Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all AO-FORSCHUNGSINSTITUT DAVOS Switzerland Net EU contribution € 0,00 Address Clavadelerstrasse 8 7270 Davos platz See on map Region Schweiz/Suisse/Svizzera Ostschweiz Graubünden / Grigioni / Grischun Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
