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Bacteria Biofilm as bio-factory for tissue regeneration

Project description

Implant infection treatment through regenerative technology

Implant-associated infections, especially those caused by biofilm-forming bacteria, pose a significant challenge, often leading to implant failure and prolonged patient suffering. Traditional treatments are limited and ineffective, unable to address the complexities of biofilm persistence. The need for innovative solutions is clear. The EIC-funded BIOACTION project aims to turn this challenge into an opportunity by developing bio-hydrogel-based implants that transform biofilm-associated infections into a resource for tissue regeneration. Using engineered liposomes and phages, BIOACTION enables programmable protein production to promote cell recruitment and tissue healing. Combining biomaterials, synthetic biology, and medicine, BIOACTION will create injectable materials and coatings for periodontal and bone infection treatments, setting a new benchmark in regenerative medicine.

Objective

BIOACTION aims at developing a new methodology in implant technology based on functionalized bio-hydrogels that will convert the negative occurrence of biofilm-associated infections, the primary cause of implant infections and failure, into a positive resource. The main goal of BIOACTION is to transform implant-associated bacteria for the programmable production of specific proteins for in vivo cell recruitment and tissue regeneration, exploiting gene sequences loaded on engineered liposomes and phages, bound to hydrogel scaffolds. BIOACTION will develop new biomimetic substrates that can transform biofilm into extracellular matrix for the regeneration of target tissues. It will establish a high versatile technology to be used as injectable materials and implant coatings for periodontal and peri-implant infection treatments. The proposed approach will be validated in two clinically relevant animal models: dental implant and permanent transcutaneous bone.
BIOACTION, would radically advance the future of infection treatment by revolutionizing the classical approaches leading to the improvement of state of care, health outcomes and to achieve huge socio-economic benefits. The project isstrongly interdisciplinary in nature involving expertise biomaterials, synthetic biology, phage and liposome technology, medicine.
As a results, this innovative approach will bring the research and knowledge far beyond the current state-of-the-art and will lead, through the planned validation, as proof-of-concept of new materials and technique with a broader application in regenerative medicine.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

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Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Net EU contribution
€ 807 500,00
Address
PIAZZALE ALDO MORO 7
00185 Roma
Italy

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Links
Total cost
€ 807 500,00

Participants (5)

Partners (1)