Project description
An artificial kidney implant
Chronic kidney (CKD) is associated with a gradual decline of kidney function and an inability to filter waste and excess fluid from the body. Artificial filtering through kidney dialysis is the standard treatment for CKD but it has multiple side effects. Funded by the European Innovation Council, the KIDNEW project proposes to develop an implantable bioartificial kidney for a more physiological treatment of CKD. The polymer-based implant will combine different sensor and filter technologies as well as kidney tubule cell monolayers. It is envisaged as a complementary approach to current dialysis solutions, contributing to the life-support of patients with renal failure.
Objective
Chronic kidney disease is a worldwide and ever-growing health crisis in which end-stage patients largely depend on intramural dialysis, placing a heavy burden on their life and on European health care systems.
KIDNEW develops groundbreaking and modular technology to enable an implantable artificial kidney with better functional kidney replacement therapy (KRT) than currently available, without need for immunosuppressive drugs and at reduced costs. It provides proof of concept on three breakthrough technologies:
1. Solid-state miniature ultra-high flux silicon (Si)-based filter with a high-density of uniform nanopores through novel block copolymer self-assembly, and with novel hemocompatible biomimetic polymer polymer brush coating connected to a photonic clotting monitoring sensor and (thrombolytic) cleansing tool;
2. Solid-state bioreactor-grown kidney tubule cell monolayers on novel biomimetic Si-wafer based membrane with bioimpedance-based monolayer integrity monitoring and monolayer repair functionality using growth-factors;
3. Solid-state integrated functional biohybrid filter and tubule exchange units stacked in parallel in a multichip to demonstrate functional implantable KRT in goats.
An implantable bioartificial kidney will provide more effective, more physiological, and economical sustainable KRT than dialysis. Eco-friendliness of proposed technologies, in line with the EU Green Deal, has recently been highlighted by the European Kidney Health Alliance. On the short to mid-term, the filter and/or tubule unit may enter niche-markets for extracorporeal use, in complementing rather than replacing current dialysis solutions.
KIDNEW brings together scientists from the fields of clinical and regenerative nephrology (UMC Utrecht, NL), regenerative pharmacology (University Utrecht, NL), chip technology (Imec NL and Imec BE), optical sensing (Optofluid Technologies OÜ, EE), blood compatible coatings (CNRS, FR), and membrane technology (Me-Sep, PL).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine nephrology
- natural sciences chemical sciences polymer sciences
- engineering and technology materials engineering coating and films
- natural sciences chemical sciences inorganic chemistry metalloids
- medical and health sciences basic medicine pharmacology and pharmacy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2022-PATHFINDEROPEN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3584 CX Utrecht
Netherlands
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