Project description
A boost for preterm newborn care
Each year, two million newborns die worldwide, often due to complications that current treatments, adapted from adult devices, fail to address adequately. Babies are not just small adults, and invasive interventions can cause lasting harm. The placenta, a life-giving organ during pregnancy, can no longer support the baby after premature birth, leaving a crucial gap in care. With this in mind, the EIC-funded ArtPlac project aims to change this by developing an artificial placenta that connects to the newborn’s umbilical vessels, mimicking in utero support. This compact device will provide lung and kidney functions while reducing side effects, improving health outcomes, and enhancing survival for up to 1.2 million newborns annually.
Objective
This Pathfinder project will establish a radical change in the treatment of newborns using an artificial placenta (ArtPlac). What drives us towards a radical new treatment approach? 2 mio. neonatal deaths that occur worldwide yearly. The technological advancements of the last fifty years were based on scaling down adult devices which are not ideal for all babies. Why? Because babies are not just small adults! In fact, the applied treatments are very invasive and cause side effects by damaging their sensitive bodies. Survivors often suffer from life-long complications or cannot live independently.
In utero, the placenta is a life-giving organ and serves as fetal lung, fetal kidney, and feeder. Because the placenta cannot be reconnected after preterm birth, we aim to continue the placental support with ArtPlac. Our novel device simply connects to the belly button for lung and kidney support while the newborn can breathe, mature, and heal. To achieve this, a novel compact and miniaturized all-in-one artificial placenta device combining lung and kidney functions will be developed. Our plug-in approach will use the natural umbilical vessels at the belly button with expandable catheters to provide a large bore vascular access like in utero. This allows ArtPlac to be driven solely by the newborn's heart like in the womb. Inline sensors will analyze blood parameters without painful collection. Feedback loops in ArtPlac will provide individual demand-driven support. Inbuilt features for hemocompatibility will prevent thrombosis and use of high-dose systemic anticoagulation with the high risk for brain bleeding. Importantly, ArtPlac allows family integrated care providing a therapy for the newborn in close connection to its family.
In summary, our visionary approach revolutionizes the treatment of newborns after birth. It will reduce brain damage and comorbidities, promote long-term health, and therefore improve the survival chances of up to 1.2 mio. newborns per year.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences clinical medicine obstetrics
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2022-PATHFINDEROPEN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
90419 NURNBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.