Advancing the diagnostic potential of CRISPR-Cas
The CRISPR-Cas technology allows for genome editing and diagnostics. The bacterial CRISPR-Cas defence mechanism generally uses a short RNA molecule that guides a Cas effector protein (or protein complex) to a matching target sequence. Several CRISPR-Cas types have been characterised in great detail. With respect to diagnostic applications, the type III CRISPR-Cas system has great potential. Although a recently established multistep diagnostic approach sparked a lot of interest, there is room for improvement. Funded by the European Research Council, the SCOPE project introduces a thermostable RNA polymerase to streamline the entire process into a single step. The project aims to provide proof of concept of the technical feasibility of this proposition to allow the diagnosis of chronic obstructive pulmonary disease.
Fields of science
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Call for proposalSee other projects for this call
Funding SchemeERC-POC - Proof of Concept Grant
6708 PB Wageningen
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