Objective
Nanotechnology has grown at an exponential rate in the last decade, finding a large application in the biomedical field. Nanoparticles are emerging as effective drug delivery tools, since they overcome most limitations of free therapeutics - while offering a series of physical/chemical advantages. Among engineered nanomaterials, selenium nanoparticles (SeNPs) have shown a growing potential as a therapeutic platform since they offer both the properties of selenium (Se) and the ones of a nanoscale system. SUNSET project aims is to design and develop a hydrogel-based nanocomposite containing multi-functionalised SeNPs, to use as an effective nanoplatform for cancer gene therapy. The designed system will be evaluated in resistant melanoma, specifically BRAF mutated lesions, which represent 66% of the cancer cases and are those that show resistance to currently available therapies, causing most cancer deaths. Here, the synthesis of SeNPs is followed by surface functionalisation with a specific small interfering RNA (siRNA) and their embedding in the polymeric phase. All the materials will be synthesised through green chemistry routes, to guarantee a low environmental impact of the procedure and its scalability and reproducibility. The anticancer activity of the nanocomposite will be evaluated both in vitro and in vivo. Overall, the combination of RNAi technology, nanomedicine and biocompatible materials – selenium and natural hydrogels – will be useful to gain a more efficient therapy, overcoming the main current challenges in the care of resistant melanomas. Moreover, the simplicity of the fabrication and the possibility to scale up the procedure, make the proposed system possibly attractive for clinical applications, promoting European Scientific Excellence. Lastly, I will have the possibility to start new cross-disciplinary collaborations that will pave the way for my future research career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- medical and health sciences clinical medicine oncology skin cancer melanoma
- medical and health sciences medical biotechnology nanomedicine
- engineering and technology nanotechnology nano-materials
- engineering and technology materials engineering nanocomposites
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
9713 GZ Groningen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.