Objective
Due to their limited protein-coding capacity, viruses have evolved sophisticated mechanisms to hijack the host molecular machinery for their own benefit; among these strategies, splicing of the viral transcripts allows them to increase their transcriptome and proteome diversity, and has been described in several virus families, including plant DNA viruses, such as geminiviruses. Geminiviruses, which cause devastating problems for the agriculture worldwide, belong to the circular, replication-associated protein (Rep)-encoding (CRESS) viruses, a phylum infecting organisms from all three domains of life and potentially sharing analogous mechanisms for genome replication. Importantly, Rep is the only protein required for viral replication, and is structurally conserved across CRESS viruses. Splicing of Rep transcripts has been anecdotally reported in circoviruses and a few minor genera of geminiviruses, with some splicing events required for a full infectivity. On the other hand, unpublished work in the host group has uncovered that i) Rep from different begomoviruses, the major genus within the Geminiviridae family, associate with the plant splicing machinery; and ii) tomato yellow leaf curl virus (TYLCV) Rep transcripts are spliced during the infection, giving rise to at least five unknown Rep protein isoforms, lacking either the oligomerization domain or part of the N-terminal DNA binding domain. We propose to uncover the importance of Rep splicing in TYLCV and to establish its relevance during the viral replication, by characterizing Rep spliced variants interactome and functions. We will also analyze the conservation of Rep splicing landscape in different geminiviruses and CRESS viruses, potentially outlining an unknown layer in the regulation of the replication of these cross-kingdom infecting viruses.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences genetics DNA
- agricultural sciences agriculture, forestry, and fisheries agriculture
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
72074 Tuebingen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.