Objective
Urinary tract infections (UTI) are severe bacterial infections of the urinary system. Low understanding of specific bacteria-host interactions and associated disease aetiologies has led to global misuse of antibiotics driving bacterial resistance. However, relevant human modelling platforms that replicate all parameters of a physiological bladder and reciprocate infection conditions are non-existent. During infection bladder stretch-mechanisms are commandeered by opportunistic bacteria to penetrate the impermeable bladder defence, that are then not appropriately cleared by antibiotics regimens. With CURIES, we will develop microfluidic bladder-on-chip systems able to replicate the dynamic biomechanical scenarios and chemically-rich environments of the bladder epithelium; the urothelium. Without appropriate models that recapitulate organ biomechanics the emergence of superpathogens is likely to never be counteracted by targeted therapeutic design, accelerating antibiotic resistance to greater crisis levels. In this MSCA application I aim to combine my bioengineering experience with the world-leading expertise of my host laboratory in epithelial mechanobiology to create dynamic simulations of human bladder-on-a-chip homeostasis and UTI infections. I will perform thorough analyses on the transcriptomic level of changes across the expanse of the urothelium with periodic filling and voiding during pathogenic and non-pathogenic infections. CURIES will have unparalleled relevance for the drug discovery industry. Bringing together such advanced methodologies will yield discoveries in molecular mechanisms impacted by bladder-pathogen interactions and enable computational modelling simulations to serve as predictive tools. By undertaking this work I will develop valuable transferable skills, increase my scientific visibility, and move closer to scientific independence. CURIES will both shape my academic career and positively impact the fight against antibiotic resistance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- natural sciences biological sciences biophysics
- medical and health sciences basic medicine physiology homeostasis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.