Objective
Large bone defects display compromised healing associated with pronounced inflammation and constitute a major clinical problem.
Recently, a range of novel biomaterial-based approaches have been engineered to promote bone regeneration. However, once these
constructs are implanted, they encounter the harsh environment of damaged tissue and often fail to induce a regenerative response.
With this MSCA Post-Doctoral Fellowship, I will address the clinical problem of large bone defect repair by harnessing extracellular
vesicles (EVs) derived from metabolically modulated macrophages to promote the immunogenic, angiogenic, and osteogenic
response in the long-term healing cascade. Specifically, my research goal is to generate an immuno-engineered scaffold with these
multitargeted regenerative EVs to maximise bone repair. The proposed multidisciplinary project will be carried out in the Tissue
Engineering Research Group (TERG) at the Royal College of Surgeons in Ireland (RCSI), which is a leading partner in the Science
Foundation Ireland (SFI) funded Advanced Materials and BioEngineering Research Centre (AMBER) under the supervision of Prof.
Annie Curtis. Additionally, as part of my project training plan, I will carry out a secondment in Trinity College Dublin, under the
supervision of Prof. David Hoey, gaining expertise in materials for bone regeneration. At the end of the fellowship, with my non-academic placement at TAmiRNA, a biotech company specialising in diagnostic and therapeutic miRNAs, I will investigate the small
RNA-cargo of the pro-regenerative EVs for the identification of new specific therapeutic targets. METABOLATE is a unique opportunity
to acquire advanced research competencies and complementary skills through interdisciplinary and inter-sectoral training. This will
allow me to mature as an independent scientist and to enrich my professional profile, preparing me for a multitude of career choices.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
D02 YN77 DUBLIN 2
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.