Objective
The catalytic activity of metalloproteins and cofactors is at the heart of biological systems’ functioning. Biological reactions occur under physiological conditions in stunning contrast with the extreme temperatures and pressures demanded by industrial processes. The evolutionary “optimal design” of enzymatic reactions led to the ubiquitous presence of key molecular motifs in several metabolic pathways, among which the iron-sulfur (FeS) clusters. Understanding how these multimetallic clusters act in Nature requires mapping their electronic and structural configuration, a challenging task that calls for new investigation methods.
In this project, the main issues of conventional spectroscopies for the characterization of FeS clusters are circumvented harnessing the potential of novel atto- and femtosecond sources, implementing element-selective impulsive vibrational spectroscopy (ES-IVS) and element-selective impulsive electronic spectroscopy (ES-IES). The impulsive excitation of FeS clusters with few-cycle pumps in the nearinfrared (for ES-IVS) and visible (for ES-IES) spectral ranges triggers their vibrational and electronic wavepacket dynamics, respectively. Using ultrashort soft X-ray pulses, the clusters’ time-domain response is monitored with element selectivity at the Fe M2,3-edge and S L2,3-edge, retrieving characteristic oscillation frequencies upon Fourier transform of the time traces.
ES-IVS will provide direct structural information of FeS clusters measuring Fe and S low-frequency vibrational spectra inaccessible with other approaches. ES-IES will map the Fe electronic states that are at the hearth of FeS catalytic activity and whose experimental observation has proven impractical. This project will establish these techniques as advanced X-ray spectroscopic tools for the investigation of FeS clusters, providing a better understanding of their role in crucial biological processes such as oxidative phosphorylation, photosynthesis and nitrogen fixation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
22607 HAMBURG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.