Project description
Peptidoglycan-binding domains in predatory bacteria: a potential route to novel antibiotics
Myxobacteria are predatory soil bacteria that actively kill bacteria of other species to consume their biomass. Understanding the mechanisms of activation of their predatory machinery could point the way to the production of novel antibiotics. A transcriptome analysis of the predator bacterium Myxococcus xanthus in a predator–prey co-culture has revealed a likely transcription regulatory response of the predator to its environment. Specifically, five genes coding for proteins with peptidoglycan-binding domains are activated along with several gene clusters related to the production of secondary metabolites. With the support of the Marie Skłodowska-Curie Actions programme, the LYSM project will attempt to discover the mechanisms behind this with a focus on the role of peptidoglycan-binding proteins during predation.
Objective
As a microbiologist with an expertise based on the study of the genetic response of microorganisms to their environment and other microorganisms, with a strong background in myxobacterial biology, I will study the induction of new antibiotic compounds in predator-prey co-cultures through the LYSM project. A transcriptome analysis of the predator bacterium Myxococcus xanthus in such conditions has revealed the induction of five genes coding for proteins with peptidoglycan-binding LysM domains together with several gene clusters involved in the production of secondary metabolites. The LYSM project will be carried out at the Department of Microbiology of the Universidad de Granada (UGR) under the supervision of Prof. Jos Muoz Dorado. Their current line of research in bacterial predation and the experience I acquired throughout my international post-doctoral stages will create a strong synergy where we will achieve greater advances than we would separately. His research group counts with several experts in myxobacteria, bacterial predation, and transcriptional regulation, and an excellent network of international collaborators, that will contribute to the success of this project.
This research project aims to discover mechanisms to awaken silent new secondary metabolites genes of M. xanthus through predator-prey interaction focusing on the role of peptidoglycan-binding proteins during predation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
- natural sciences biological sciences genetics
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biological behavioural sciences ethology biological interactions
- natural sciences biological sciences biological behavioural sciences behavioural ecology
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
18071 GRANADA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.