Project description
Advanced kidney organoids chronic kidney disease therapy
Chronic kidney disease (CKD) is associated with the gradual loss of kidney function, leading to complications such as high blood pressure, anaemia, and kidney failure. Current treatment options are limited and aim at slowing down disease progression. Funded by the Marie Skłodowska-Curie Actions programme, the KNOVV project aims to develop alternative solutions based on tissue engineering and regenerative medicine. To achieve this, researchers will develop innovative renal organoids with improved properties and structure that closely mimic the native organ. With optimised protocols, the project will employ hydrogels to generate mature and functional bioprinted renal organoids, thereby significantly advancing the field of CKD treatment.
Objective
KNOVV aims at directing nephron spatial orientation within renal organoids to mimic in vivo kidney development.
Chronic kidney disease (CKD) is an increasing socio-economic burden, with 100 million people affected in Europe; available treatments are limited to dialysis and transplants.
Tissue engineering and regenerative medicine (TERM) aims at developing in vivo–like organs, using in vitro three-dimensional (3D) systems as new therapies. Promising TERM therapies involving self-organized renal organoids from human induced pluripotent stem cells (hiPSC) are being investigated. These kidney organoids contain the appropriate cells although heterogeneity, immature stage and lack of the spatially specific nephron orientation are still major bottlenecks. These limitations impair microphysiological form and function, which limits their research utility and clinical applications. I hypothesize that inducing spatial nephron orientation in kidney organoids will result in improved maturation and function closely mimicking the in vivo organ. To achieve this, I will optimize protocols to generate renal organoids from hiPSC.
I will identify molecules to inhibit or induce glomerulogenesis (glomeruli formation), and develop glomerulogenesis-inducing and -inhibiting hydrogels for bioprinting renal organoids. Immunostaining, qPCR, and functional assays will be used to evaluate the morphology and function of the 3D bioprinted renal organoid construct.
KNOVV will strengthen my research and academic profiles, broaden my knowledge and experience by combining developmental biology, TERM and biofabrication to improve renal organoids. My ambition is that the bioprinted renal organoid constructs with spatially directed nephrons will enable unprecedented microphysiological maturation and function. This will allow a leap beyond the current organoids state of art and ultimately lead us closer to clinical translation, offering an alternative for the growing CKD population.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
6200 MD Maastricht
Netherlands
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