Objective
The NanoHeadTail proposes a novel and original approach combining fluorescence microscopy and nanotechnology to resolve the morphological and rheological properties of the brain extracellular space (ECS) at the nanoscale. Current methods allow to determine the local dimensions and fluidity of the ECS, but they do not allow to resolve its structural complexity and are limited to an analysis in 2D. This project proposes the simultaneous monitoring of the position, the translational and rotational diffusion of fluorescent probes over time and in 3D, allowing to determine the volumetric structure, fluidity and inner organization of the ECS locally. For that, a novel type of asymmetric probes will be designed based on the localized functionalization of single-walled carbon nanotubes with fluorescent color centers at their ends, analyzed using a custom cutting-edge fluorescence microscope and tested in live brain tissues from mice models of the Parkinson’s disease. The applicant will bring his strong expertise in the photophysics and chemistry of carbon nanotubes, critical for the preparation of the probes. In parallel, the fellow will gain a high-level hands-on training on optics assembly, super resolution microscopy and single particle tracking, imaging analysis and neurosciences. The project will be performed at the IOGS-LP2N (CNRS/Univ. Bordeaux), a leading French research institution, under the supervision of Dr. Laurent Cognet expert in the single particle tracking of nanoobjects. The proposal contains well-identified work packages which will ensure efficient science development but also project management, career development, training, technology transfer and communication. The fellow’s expertise, the hosting lab, the infrastructure, facilities and the mentoring will guarantee the successful execution of the NanoHeadTail goals and will allow the applicant to reach a high level of professional maturity and to develop his career as an independent researcher.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- engineering and technology materials engineering colors
- engineering and technology nanotechnology
- natural sciences physical sciences optics microscopy
- medical and health sciences basic medicine neurology neurodegenerative diseases parkinson
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
91120 Palaiseau
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.