Objective
Heart failure is a major global public health problem affecting over 23 million patients worldwide. There are no effective therapies for
heart failure that regenerate the damaged heart muscle following injury such as a myocardial infarction. The adult mammalian heart
has an extremely limited intrinsic capacity for regeneration due to the fact that mature cardiomyocytes are unable to proliferate. To
date, attempts to re-induce proliferation in mature cardiomyocytes of the adult heart have not yet been translated into the human
clinical context. Much remains to be learned about molecular mechanisms controlling cardiomyocyte proliferation in humans if the
therapeutic potential for cardiac regeneration is to be realised.
With my extensive training and expertise in molecular and stem cell biology I plan to generate and exploit an innovative live cell cycle
reporter-based screening platform to identify Transcription Factors (TFs) that can be induce cardiomyocyte proliferation.
The three major objectives of this research proposal are:
1. Develop a high-content screening system to monitor cardiomyocyte proliferation in 3D human cardiac organoids, which will then be used to:
2. Identify (combinations of) TFs that drive the human cardiomyocyte cell cycle.
3. Assess the therapeutic potential of TF activation for cardiac regeneration in a pre-clinical human cardiac model system.
I will receive extensive training in the ex vivo cardiac tissue culture system (objective 3), which will complement my proven expertise in the generation of (genetically modified) 3D cardiac organoids and knowledge on cell cycle regulation (objective 1 & 2). Altogether, the tool development, results and training obtained during this project will put me in the forefront of the cardiac regenerative field.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2333 ZA Leiden
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.