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Self-assembled 2D Chiral Plasmene Nanosheets for Biomarker Detection Based on Surface-Enhanced Raman Scattering

Project description

Self-assemble 2D chiral plasmene nanosheets: ultrasensitive biomarker and chirality detectors

Surface plasmons are coherent and collective electron oscillations along the surface of a metal. In the case of plasmonic metal nanoparticles, this collective oscillation of conduction electrons yields remarkable optical properties that can be tuned under the right conditions. With the support of the Marie Skłodowska-Curie Actions programme, the ChirPlasBiosensing project aims to develop a novel functional chiral plasmonic biosensing platform from self-assembled 2D chiral plasmene nanosheets. The 2D plasmene nanosheets (one-particle-thick superlattices of plasmonic nanoparticles) will be formed from colloidal chiral plasmonic nanoparticles of different morphologies and optimised chiroptical responses. These nanoparticles will be synthesised via chirality transfer from soft chiral growth-directing molecules such as amino acids and peptides.

Objective

In this project, I will develop chemical methods to synthesize colloidal chiral plasmonic nanoparticles and assemble them into 2D plasmene nanosheets. Chiral components on the surface of metal nanocrystals enantioselectively interact with chiral growth-directing molecules, such as amino acids and peptides, leading to the asymmetric evolution of chiral plasmonic metal nanoparticles. The chirality transfer from soft chiral molecules to inorganic metal surfaces derive from the highly twisted surface features on the nanoparticles induced by the chiral molecules during overgrowth. I will synthesize chiral plasmonic nanoparticles with different morphologies, finely tune the twisted surface elements, adjust their interparticle spacings and orientation, and optimize their chiroptical responses. Highly chiral 2D graphene-like plasmonic superlattices, or plasmene nanosheets, will then be fabricated on flexible substrates to serve as all-hot-spot practical chiral sensing platforms via control over interparticle spacing and orientation. A novel functional chiral plasmonic biosensing platform will be constructed by the self-assembled 2D chiral plasmene nanosheets, based on surface-enhanced Raman scattering, for ultrasensitive biomarker detection and chirality discrimination.

Fields of science (EuroSciVoc)

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

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HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

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(opens in new window) HORIZON-MSCA-2022-PF-01

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Coordinator

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 165 312,96
Address
PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
20009 San Sebastian
Spain

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Region
Noreste País Vasco Gipuzkoa
Activity type
Research Organisations
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Total cost

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