Objective
The placenta nourishes the fetus and removes its waste products in pregnancy. Fundamental to its function is the healthy development of an extensively branched tree-like structure known as the vascular tree. In pathological pregnancies, abnormalities have been found in placental structure and function. Impaired uteroplacental blood flow can lead to pregnancy disorders such as fetal growth restriction (FGR), a condition in which the fetus does not grow physiologically. FGR has lifelong consequences for both fetus and mother, affecting 8-10% of pregnancies and contributing to 30% of stillbirths. The placenta is inaccessible to in vivo measurements due to technological and ethical constraints. Ultrasound is the most routinely used clinical imaging tool for screening the placenta; however, it is limited in spatial resolution. Placental function can be also assessed via Magnetic Resonance Imaging (MRI) which is safe during pregnancy; however, MRI models cannot measure blood flow changes in the placental vascular tree. Complementary to imaging, in silico models are increasingly used to probe complex cardiovascular problems. Attempts to model blood flow in the placental vasculature are based on oversimplified assumptions while being limited by the data they have been informed or validated against with. Here, an integrated hemodynamic model of the placental vasculature will be developed using novel ex vivo computed tomography data and computational fluid dynamics. This project will innovate by delivering a computer-based framework, InSilicoPlacenta, which will offer a comprehensive understanding of the structural and functional abnormalities with FGR. We will combine medical imaging with in silico models to infer placental tissue properties of the entire placental vasculature. The long-term impacts of the proposed framework are expected to change clinical diagnosis and management of high-risk pregnancies by reducing stillbirths and improving neonatal outcomes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine obstetrics
- medical and health sciences clinical medicine embryology
- natural sciences physical sciences acoustics ultrasound
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1678 Nicosia
Cyprus
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.