Objective
Accurate communication between the central nervous system and the periphery requires rapid and efficient transmission of action potentials along the axon. Glial cells and neurons cooperate to regulate axonal conduction, and normal physiology of the nervous system is strongly dependent on the crosstalk between the two systems. Neurofilaments (NFs), the most abundant components of the neuronal cytoskeleton are a key target of the crosstalk that regulates electrical conductance. Nevertheless, the mechanisms by which the glial-neuron crosstalk regulates NF dynamics are currently not well understood. Yet this knowledge is of great importance, as disturbances in this system underlie disease mechanisms in various neurodegenerative diseases.
In the GliaNFish project, top-notch techniques will be combined to capture for the very first time real-time dynamics of NF transport and NF-protein interactions in a living organism (zebrafish larvae), to understand the role of glia-neuron crosstalk in nervous system physiology. The project encompasses three objectives which aim to investigate: 1) NF organization and dynamics in vivo; 2) the impact of (de)myelination on NF organization and dynamics; and 3) the molecular players involved in the outside-in signalling cascade that regulate NF dynamics. The outcomes of the project will advance our understanding of NF dynamics and signalling in vivo, and on how myelinating glia and neurons synergize to enable signal conduction in the nervous system. This knowledge may permit in the future to explore how disturbances in this system lead to disease and will pave the way for novel therapeutic strategies towards NF dynamics. Overall, this project is extremely timely and relevant, as the social and economic burden of neurodegenerative diseases is expected to rise significantly in the upcoming years.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine physiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.