Objective
Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). One million people in Europe have MS, experiencing a significantly reduced quality of life and dying 7-14 years younger than average. The annual burden on European economies is ~€35B. Epstein-Barr virus (EBV) infects almost all Europeans and is aetiologically linked to MS with infection increasing disease risk 32-fold. Despite the huge personal, societal and economic impacts of MS, the underlying role of EBV in its development remains poorly understood.
DREAMS will explore how EBV contributes to MS development. To do this, the Postdoctoral Fellow (PF) will utilise a novel humanised mouse model which harbours the major genetic risk factor for MS and is permissive for EBV infection. This model displays characteristics common with human MS, including CNS immune cell infiltration. Applying multiplex immunofluorescence, the PF will explore the nature of this immune infiltrate and how it is influenced by drugs used to treat MS, focussing on inhibitors of S1PR signalling. Combined with mechanistic in vitro studies to determine how these drugs interact with EBV-infected B-cells and EBV-specific T-cells, this work will allow new insights into how S1PR modulation affects MS immunopathology. As such, this research aligns with the Horizon Europe Health cluster and several UN sustainable goals, and meets Open Science, Gender Equality, Supervision and Green Charter guidelines.
The PF will receive training in humanised mouse models, in vivo imaging and flow cytometry during an outgoing 24-month phase at the University of Zurich (Switzerland). This will be followed by a 12-month return phase at the University of Limerick (Ireland), learning in vitro T-cell assays. The PF will leverage the interdisciplinary supervisory team to meet the research & training objectives outlined, in preparation for an independent research career in the field of virus-associated diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences microbiology virology
- medical and health sciences basic medicine neurology multiple sclerosis
- medical and health sciences basic medicine immunology
- social sciences sociology gender studies gender equality
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
- Limerick
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.