Objective
Conceptually new synthetic membrane transporters constitute a key challenge for supramolecular chemistry and materials sciences. To date, the transport of hydrophilic bioactive substances across membranes has exploited the amphiphilic character of carriers and cargos such as in lipids or other cationic amphiphiles. However, amphiphilic molecules face limitations due to intrinsic features such as toxicity associated to their detergent-like behaviour and their tendency to aggregate. This year, it has been described that superchaotropic boron clusters can transport a range of hydrophilic chemical substances across lipid membranes and inside cells. This new concept supports that the chaotropic effect can guide the design of an entirely new class of membrane carriers. However, until now, boron clusters have only been used as non-covalent carriers of the cargo of interest. The main objective of this action is to investigate, for the first time, the covalent introduction of superchaotropic substituents into prototype peptide sequences and evaluate their potential to be self-transported across membranes. A selection of simple anionic, cationic and hydrophobic peptides will be equipped with boron clusters modified amino acids and screened in model membranes and in cell assays. Unknown concepts and revolutionary molecules could emerge from this initial study. For example, the introduction of anionic boron clusters into cationic short peptides could give rise to a new class of (strongly hydrophilic) zwitterionic self-transported biomolecular scaffolds. We also suspect that switching hydrophobic for anionic chaotropic residues will decrease aggregation propensity but increase membrane transport efficiency of amphiphilic bioactive peptides. This new application of chaotropic cluster will impact the field of membrane transport by using more controllable, non-aggregating and less toxic synthetic vehicles.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences chemical sciences inorganic chemistry metalloids
- natural sciences chemical sciences organic chemistry amines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
15782 SANTIAGO DE COMPOSTELA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.