Objective
Damage to the osteochondral interface (OCI) is a serious health problem associated with the development of osteoarthritis affecting the lives of millions of people. However, current treatment tools have imitations leading to unsatisfactory clinical outcomes. This project aims to solve the problem by a complex approach combining and advancing recent findings in the field of tissue engineering (TE). It is accepted that patient cells can be seeded onto artificial scaffolds containing biologically active substances (BASs) to stimulate these cells to new tissue formation. We take the view that the scaffold should consist of a soft part and a sufficiently stiff part to avoid the formation of unwanted fibrocartilage. We will use cryogelation and 3D-printed bioactive glass to prepare multiphasic scaffolds that can carry regulatory signals for adipose-derived stem cells (ADSCs). Our research objectives are to develop 1) a stiff scaffold with a graded structure matching the morphology of the subchondral bone and able to be loaded by BASs to facilitate osteogenesis, 2) a soft scaffold based on a cryogel enriched by BASs to facilitate chondrogenesis, and 3) a combined scaffold matching the zonal structure of OCI to enhance its regeneration. 4) We will use ADSCs and modern ex vivo testing protocols to evaluate the potential of the scaffold to meet the needs of OCI TE, and to direct future research to in vivo testing and commercialization. The research will be conducted within the academic structures of the University of Chemistry and Technology (UCT) in Prague, Czech Republic, in collaboration with the Biotechnology and Biomedicine Center in Vestec (BIOCEV) near Prague, under the supervision of Prof. Jan Merna and Prof. Bacakova.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering
- social sciences political sciences government systems
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
166 28 PRAHA
Czechia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.