Objective
So far medicine has not solved the workings of a formidable and scientifically challenging aspect of cancer: metastasis, the migration of circulating tumor cells (CTC) through the body. In this highly interdisciplinary project, expertise and techniques from fluid dynamics are employed to study how CTC move through the vascular network and what prompts them to do so. The complex interplay among hydrodynamics, biophysics of intracellular interactions, and biochemical signaling within vascular networks is unknown. Our understanding of these underlying processes is hindered by the complex heterogeneity in the vascular network, comprising of capillaries, veins and arteries with a wide range of size and structural diversity. To unravel these processes I bring my expertise in fluid dynamics and porous media together with the state-of-the-art facilities on experimental cancer mechanobiology and multiscale modeling at the host and secondment institutes. I will conduct microfluidic experiments and simulations by simplifying the vascular network as strategically designed pore-network models. First, I will study the two-way interactions between the heterogeneous flow field and the deformable CTCs that control their overall transport, deformation and trapping. A heterogeneous flow field also induces a spatially nonuniform scalar concentration across the medium. CTCs are highly sensitive to certain biochemicals that can alter motility and invasiveness of CTCs. I will investigate how the local gradients of such biochemicals in a heterogeneous microsystem influence CTC migration. Finally, I will study the collective migration of CTC clusters through the system and quantify the dynamic intracellular interaction by measuring membrane tension and intracellular adhesion forces. These investigations will provide novel understandings on cancer metastasis that I will strategically communicate to research communities, stakeholders and general public.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences biophysics
- natural sciences computer and information sciences computational science multiphysics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2628 CN DELFT
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.