Revolutionary silk-based bioink for 3D printing of ex vivo bone marrow models to advance drug development and personalized medicine

Project Information

SILKink

Grant agreement ID: 101113073

DOI

10.3030/101113073

Project closed

EC signature date 26 April 2023

Start date 1 June 2023

End date 31 May 2026

Funded under

The European Innovation Council (EIC)

Total cost

€ 2 494 687,50

EU contribution

€ 2 494 687,50

2 494 687,50

Coordinated by

UNIVERSITA DEGLI STUDI DI PAVIA
Italy

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Publications

Bioprinting Soft 3D Models of Hematopoiesis using Natural Silk Fibroin-Based Bioink Efficiently Supports Platelet Differentiation (Adv. Sci. 18/2024)

Author(s): Christian Andrea Di Buduo, Marco Lunghi, Volodymyr Kuzmenko, Pierre-Alexandre Laurent, Giulia Della Rosa, Claudia Del Fante, Damian Edward Dalle Nogare, Florian Jug, Cesare Perotti, Koji Eto, Alessandro Pecci, Itedale Namro Redwan, Alessandra Balduini
Published in: Advanced Science, 2024, ISSN 2198-3844
Publisher: Wiley-VCH GmbH, Weinheim
DOI: 10.1002/advs.202470103

Bioprinting a Silk-Based 3D Bone Marrow Model for Chemotherapy-Induced Thrombocytopenia

Author(s): Di Buduo CA, Migliavacca M, Malara A, Balduini A
Published in: Research and Practice in Thrombosis and Haemostasis
DOI: 10.1016/J.RPTH.2026.10513

Newly Identified Roles for PIEZO1 Mechanosensor in Controlling Normal Megakaryocyte Development and in Primary Myelofibrosis

Author(s): Abbonante V, Karkempetzaki IA, Di Buduo CA, et al
Published in: HemaSphere
DOI: 10.1097/01.HS9.0000970860.68462

Bioprinting Soft 3D Models of Hematopoiesis using Natural Silk Fibroin-Based Bioink Efficiently Supports Platelet Differentiation

3D Silk-Based Bone Marrow Models Identify Autophagy As a Critical Mechanism in Red Blood Cell Production

Author(s): Christian Andrea Di Buduo, Francesca Careddu, Samuele Metti, Cesare Perotti, Claudia Del Fante, Paola Braghetta, Giampaolo Minetti, Luca Malcovati, Alessandra Balduini
Published in: Blood, Issue 144, 2024, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/BLOOD-2024-209731

In vitro studies of human erythropoiesis using a 3D silk-based bone marrow model that generates erythroblastic islands

Author(s): Christian A. Di Buduo, Francesca Careddu, Samuele Metti, Marco Lunghi, Santo Diprima, Virginia Camilotto, Giovanna Bruni, Umberto Gianelli, Delfina Tosi, Cesare Perotti, Claudia Del Fante, Mario Cazzola, Paola Braghetta, David L. Kaplan, Giampaolo Minetti, Luca Malcovati, Alessandra Balduini
Published in: Blood Advances, Issue 9, 2025, ISSN 2473-9529
Publisher: American Society of Hematology
DOI: 10.1182/BLOODADVANCES.2024014905

Newly identified roles for PIEZO1 mechanosensor in controlling normal megakaryocyte development and in primary myelofibrosis

Author(s): Abbonante V, Karkempetzaki AI, Leon C, Krishnan A, Huang N, Di Buduo CA, Cattaneo D, Ward CM, Matsuura S, Guinard I, Weber J, De Acutis A, Vozzi G, Iurlo A, Ravid K, Balduini A.
Published in: American Journal of Hematology, 2024, ISSN 1096-8652
Publisher: Wiley Periodicals, LLC.
DOI: 10.1002/ajh.27184

Intellectual Property Rights

SILK FIBROIN AND RELATED USE FOR 3D BIOPRINTING

Application/Publication number: 22 709805
Date: 2022-02-24
Applicant(s): CELLINK BIOPRINTING AB

SILK FIBROIN AND RELATED USE FOR 3D BIOPRINTING

Application/Publication number: 22 709805
Date: 2022-02-24
Applicant(s): UNIVERSITA DEGLI STUDI DI PAVIA

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Deliverables

Publications

Intellectual Property Rights

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