Computational, Chemical and Biotechnology Solutions to Improved DNA Data Storage: from In-Product Information and Cryptography to Long-Term Archiving

Información del proyecto

DiDAX

Identificador del acuerdo de subvención: 101115134

DOI

10.3030/101115134

Fecha de la firma de la CE 3 Julio 2023

Fecha de inicio 1 Noviembre 2023

Fecha de finalización 31 Octubre 2027

Financiado con arreglo a

• The European Innovation Council (EIC)

Coste total

€ 4 543 583,75

Aportación de la UE

€ 4 543 583,75

Coordinado por

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

Website and project logo

Website and project logo information, also with social media links.

Documents, reports (3)

State of the art and market needs for authentication protocols

A report describing the state of the art and the commercial need for authentication and in-product documentation.

Plan for Communication and Dissemination Activities

Plan for Communication and Dissemination Activities including outline of workshops, plan for website improvements, and possibly other dissemination activities.

Report on Portfolio activities for reporting period 1

The report will present the collaboration activities that have been carried out in reporting period 1 and contain relevant materials (e.g., power point presentations, minutes of the meetings, etc.). It also explains how the Portfolio activities and the EIC proactive project management approach contribute to the achievement the project objectives and help the transition to market.The report will be submitted at the end reporting period 1 and will be assessed in the context of projects review for the corresponding reporting period (M12).

Data Management Plan (1)

Data Management Plan

Data Management Plan established and described.

Publicaciones

Conference proceedings (20)

Constrained Coding for Composite DNA: Channel Capacity and Efficient Constructions

Autores: Tuan Thanh Nguyen, Chen Wang, Kui Cai, Yiwei Zhang, Zohar Yakhini
Publicado en: 2025 IEEE International Symposium on Information Theory (ISIT), 2025
Editor: IEEE
DOI: 10.48550/ARXIV.2501.10645

Sequence Reconstruction Over Coloring Channels for Protein Identification

Autores: Jessica Bariffi, Antonia Wachter-Zeh, Eitan Yaakobi
Publicado en: 2025 IEEE International Symposium on Information Theory (ISIT), 2025
Editor: IEEE
DOI: 10.48550/ARXIV.2508.02229

Complex DNA Synthesis Sequences

Autores: Boaz Moav, Eitan Yaakobi, Ryan Gabrys
Publicado en: 2025 IEEE International Symposium on Information Theory (ISIT), 2025
Editor: IEEE
DOI: 10.48550/ARXIV.2510.21253

Correcting Multiple Substitutions in Nanopore-Sequencing Reads

Autores: Anisha Banerjee, Yonatan Yehezkeally, Antonia Wachter-Zeh, Eitan Yaakobi
Publicado en: 2025 IEEE International Symposium on Information Theory (ISIT), 2025
Editor: IEEE
DOI: 10.48550/ARXIV.2505.02447

Near Optimal Code Construction for the Adversarial Torn Paper Channel with Edit Errors

Autores: Maria Abu-Sini, Reinhard Heckel
Publicado en: 2025 IEEE International Symposium on Information Theory (ISIT), 2025
Editor: IEEE
DOI: 10.48550/ARXIV.2601.14088

DeepDIVE: Optimizing Input-Constrained Distributions for Composite DNA Storage via Multinomial Channel

Autores: Adir Kobovich, Eitan Yaakobi, Nir Weinberger
Publicado en: 2025 IEEE International Symposium on Information Theory (ISIT), 2025
Editor: IEEE
DOI: 10.48550/ARXIV.2501.15172

Coding for Ordered Composite DNA Sequences

Autores: Besart Dollma, Ohad Elishco, Eitan Yaakobi
Publicado en: 2025 IEEE International Symposium on Information Theory (ISIT), 2025
Editor: IEEE
DOI: 10.48550/ARXIV.2509.26119

Coding for Composite DNA to Correct Substitutions, Strand Losses, and Deletions

Autores: Frederik Walter, Omer Sabary, Antonia Wachter-Zeh, Eitan Yaakobi
Publicado en: 2024 IEEE International Symposium on Information Theory (ISIT), 2024
Editor: IEEE
DOI: 10.1109/ISIT57864.2024.10619202

An Optimal Sequence Reconstruction Algorithm for Reed-Solomon Codes

Autores: Shubhransh Singhvi, Roni Con, Han Mao Kiah, Eitan Yaakobi
Publicado en: 2024 IEEE International Symposium on Information Theory (ISIT), 2024
Editor: IEEE
DOI: 10.1109/ISIT57864.2024.10619163

Decoding Insertions/Deletions via List Recovery

Autores: Anisha Banerjee, Roni Con, Antonia Wachter-Zeh, Eitan Yaakobi
Publicado en: 2025 IEEE International Symposium on Information Theory (ISIT), 2025
Editor: IEEE
DOI: 10.48550/ARXIV.2505.02452

Coding for Synthesis Defects

Autores: Ziyang Lu, Han Mao Kiah, Yiwei Zhang, Robert N. Grass, Eitan Yaakobit
Publicado en: 2024 IEEE Information Theory Workshop (ITW), 2024
Editor: IEEE
DOI: 10.48550/ARXIV.2405.02080

The Labeled Coupon Collector Problem

Autores: Andrew Tan, Oriel Limor, Daniella Bar-Lev, Ryan Gabrys, Zohar Yakhini, Paul H. Siegel
Publicado en: 2025 IEEE Information Theory Workshop (ITW), 2025
Editor: IEEE
DOI: 10.48550/ARXIV.2507.15231

Error-Correcting Codes for Labeled DNA Sequences

Autores: Dganit Hanania, Eitan Yaakobi
Publicado en: 2025 IEEE International Symposium on Information Theory (ISIT), 2025
Editor: IEEE
DOI: 10.48550/ARXIV.2511.01280

Coding for Strand Breaks in Composite DNA

Autores: Frederik Walter, Yonatan Yehezkeally
Publicado en: 2025 IEEE International Symposium on Information Theory (ISIT), 2025
Editor: IEEE
DOI: 10.48550/ARXIV.2501.15851

Correcting a Single Deletion in Reads from a Nanopore Sequencer

Autores: Anisha Banerjee, Yonatan Yehezkeally, Antonia Wachter-Zeh, Eitan Yaakobi
Publicado en: 2024 IEEE International Symposium on Information Theory (ISIT), 2024
Editor: IEEE
DOI: 10.1109/ISIT57864.2024.10619468

Sequential Decoding of Multiple Traces Over the Syndrome Trellis for Synchronization Errors

Autores: Anisha Banerjee, Lorenz Welter, Alexandre Graell I Amat, Antonia Wachter-Zeh, Eirik Rosnes
Publicado en: ICASSP 2025 - 2025 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), 2025
Editor: IEEE
DOI: 10.48550/ARXIV.2410.07120

Studying the Cycle Complexity of DNA Synthesis

Autores: Amit Zrihan, Eitan Yaakobi, Zohar Yakhini
Publicado en: 2024 IEEE Information Theory Workshop (ITW), 2024
Editor: IEEE
DOI: 10.48550/ARXIV.2412.05865

Error-Correcting Codes for Combinatorial Composite DNA

Autores: Omer Sabary, Inbal Preuss, Ryan Gabrys, Zohar Yakhini, Leon Anavy, Eitan Yaakobi
Publicado en: 2024 IEEE International Symposium on Information Theory (ISIT), 2024
Editor: IEEE
DOI: 10.1109/ISIT57864.2024.10619334

Rank Modulated Composite Encoding for Data Storage in DNA

Autores: Tomer Cohen, Zhiying Wang, Eitan Yaakobi, Zohar Yakhini
Publicado en: 2025 13th International Symposium on Topics in Coding (ISTC), 2025
Editor: IEEE
DOI: 10.1109/ISTC65386.2025.11154607

Representing Information on DNA Using Patterns Induced by Enzymatic Labeling

Autores: Daniella Bar-Lev, Tuvi Etzion, Eitan Yaakobi, Zohar Yakhini
Publicado en: 2024 IEEE International Symposium on Information Theory (ISIT), 2024
Editor: IEEE
DOI: 10.1109/ISIT57864.2024.10619227

Peer reviewed articles (20)

More on codes for combinatorial composite DNA

Autores: Zuo Ye, Omer Sabary, Ryan Gabrys, Eitan Yaakobi, Ohad Elishco
Publicado en: Designs, Codes and Cryptography, Edición 93, 2025, ISSN 0925-1022
Editor: Springer Science and Business Media LLC
DOI: 10.1007/S10623-025-01634-8

Sequencing Coverage Analysis for Combinatorial DNA-Based Storage Systems

Autores: Inbal Preuss, Ben Galili, Zohar Yakhini, Leon Anavy
Publicado en: IEEE Transactions on Molecular, Biological, and Multi-Scale Communications, Edición 10, 2024, ISSN 2372-2061
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TMBMC.2024.3408053

Error characterization and error correction approaches in combinatorial DNA-based storage

Autores: Inbal Preuss, Omer Sabary, Ryan Gabrys, Zohar Yakhini, Eitan Yaakobi, Leon Anavy
Publicado en: Scientific Reports, Edición 16, 2026, ISSN 2045-2322
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41598-026-38599-0

Sequence Reconstruction for Substitution Channel: New Sufficient Conditions and Algorithms

Autores: Chen Wang, Eitan Yaakobi, Yiwei Zhang
Publicado en: IEEE Transactions on Information Theory, Edición 72, 2026, ISSN 0018-9448
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.48550/ARXIV.2606.05454

DNA-Based Chemical Unclonable Functions for Cryptographic Anticounterfeit Tagging of Pharmaceuticals

Autores: Anne M. Luescher, Wendelin J. Stark, Robert N. Grass
Publicado en: ACS Nano, Edición 18, 2024, ISSN 1936-0851
Editor: American Chemical Society (ACS)
DOI: 10.1021/acsnano.4c10870

Efficiency of Digital Photolithographic Synthesis of Large, High-Quality DNA Libraries and Microarrays using a Guanine O6 Dephosphitylation Strategy

Autores: Santra Santhosh, Sharon Istvánffy, Omer Sabary, Eitan Yaakobi, Maya Giridhar, Jürgen Behr, Mark M. Somoza
Publicado en: Communications Chemistry, Edición 8, 2025, ISSN 2399-3669
Editor: Springer Science and Business Media LLC
DOI: 10.26434/CHEMRXIV-2025-F706F

Channels with Input-Correlated Synchronization Errors

Autores: Roni Con, João Ribeiro
Publicado en: IEEE Transactions on Information Theory, 2026, ISSN 0018-9448
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.48550/ARXIV.2504.14087

Robust Gray Codes Approaching the Optimal Rate

Autores: Roni Con, Dorsa Fathollahi, Ryan Gabrys, Mary Wootters, Eitan Yaakobi
Publicado en: IEEE Transactions on Information Theory, Edición 71, 2025, ISSN 0018-9448
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.48550/ARXIV.2406.17689

Challenges for error-correction coding in DNA data storage: photolithographic synthesis and DNA decay

Autores: Andreas L. Gimpel, Wendelin J. Stark, Reinhard Heckel, Robert N. Grass
Publicado en: Digital Discovery, 2024, ISSN 2635-098X
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4DD00220B

Exploring the intersection of natural sciences and information technology via entropy and randomness

Autores: Anne M. Luescher, Reinhard Heckel, Robert N. Grass
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.3929/ETHZ-C-000782746

One Code Fits All: Strong Stuck-At Codes for Versatile Memory Encoding

Autores: Roni Con, Ryan Gabrys, Eitan Yaakobi
Publicado en: IEEE Transactions on Information Theory, Edición 71, 2025, ISSN 0018-9448
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.48550/ARXIV.2403.19061

Anonymous Shamir’s Secret-Sharing via Reed–Solomon Codes Against Permutations, Insertions, and Deletions

Autores: Roni Con
Publicado en: IEEE Transactions on Information Theory, Edición 71, 2025, ISSN 0018-9448
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.48550/ARXIV.2412.17003

Error-Correcting Codes for Nanopore Sequencing

Autores: Anisha Banerjee, Yonatan Yehezkeally, Antonia Wachter-Zeh, Eitan Yaakobi
Publicado en: IEEE Transactions on Information Theory, Edición 70, 2024, ISSN 0018-9448
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TIT.2024.3380615

Large‐Scale Distribution of Physical Data Using DNA‐of‐Things Technology in Newspaper Printing

Autores: Francesca Granito, Andreas L. Gimpel, Wendelin J. Stark, Reinhard Heckel, Robert N. Grass
Publicado en: Small, Edición 22, 2026, ISSN 1613-6810
Editor: Wiley
DOI: 10.1002/SMLL.202511931

Efficient DNA-based data storage using shortmer combinatorial encoding

Autores: Inbal Preuss, Michael Rosenberg, Zohar Yakhini, Leon Anavy
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41598-024-58386-z

Improved Constructions of Linear Codes for Insertions and Deletions

Autores: Roee Gross, Roni Con, Eitan Yaakobi
Publicado en: IEEE Transactions on Information Theory, Edición 72, 2026, ISSN 0018-9448
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.48550/ARXIV.2509.26077

Color-corrected and high-contrast catadioptric relay for maskless high-resolution nucleic acid photolithography

Autores: Timm Michel, Jürgen Behr, Hamed Sabzalipoor, Gisela Ibáñez-Redín, Jory Lietard, Thomas Schletterer, Max Funck, Mark M. Somoza
Publicado en: Optics Express, Edición 33, 2025, ISSN 1094-4087
Editor: Optica Publishing Group
DOI: 10.48550/ARXIV.2411.06466

Comparison of state-of-the-art error-correction coding for sequence-based DNA data storage

Autores: Andreas L. Gimpel, Alex Remschak, Wendelin J. Stark, Reinhard Heckel, Robert N. Grass
Publicado en: Nature Communications, Edición 17, 2026, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1101/2025.07.11.664297

Reed–Solomon Codes Against Insertions and Deletions: Full-Length and Rate-1/2 Codes

Autores: Peter Beelen, Roni Con, Anina Gruica, Maria Montanucci, Eitan Yaakobi
Publicado en: IEEE Transactions on Information Theory, Edición 72, 2026, ISSN 0018-9448
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.48550/ARXIV.2501.11371

Cover Your Bases: How to Minimize the Sequencing Coverage in DNA Storage Systems

Autores: Daniella Bar-Lev, Omer Sabary, Ryan Gabrys, Eitan Yaakobi
Publicado en: IEEE Transactions on Information Theory, Edición 71, 2025, ISSN 0018-9448
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.48550/ARXIV.2305.05656

Other (1)

An open-source advanced maskless synthesizer for light-directed chemical synthesis of large nucleic acid libraries and microarrays

Autores: Jürgen Behr, Timm Michel, Maya Giridhar, Santra Santhosh, Arya Das, Hamed Sabzalipoor, Tadija Kekić, Etkin Parlar, Igor Ilić, Gisela Ibáñez-Redín, Erika Schaudy, Jory Lietard, Thomas Schletterer, Max Funck, Mark Somoza
Publicado en: 2024
Editor: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2024-j4c90