Project description
Revolutionising diabetes management with multi-metabolite monitoring
For millions of people with diabetes reliant on insulin treatment, managing the condition poses an unrelenting challenge. Traditional glucose-only monitoring falls short in providing comprehensive insights into metabolic health, leading to acute complications and long-term risks. In this context, the EIC-funded MuSiC4Diabetes project aims to shift to multi-metabolite monitoring by covering glucose as well as lactate and 3 ß OH-butyrate. At its core is a maintenance-free implanted microelectromechanical system, or MEMS, pump using the peritoneal route, enabling continuous physiologic insulin delivery through algorithmic precision. The goal is not just glucose control but also to address metabolic health, mirroring physiological insulin action. The vision of an implantable artificial organ offers insulin-treated patients an unobtrusive life, reducing mortality for type 1 diabetes patients.
Objective
It will be a radically new approach for long-term continuous monitoring of insulin-treated persons with diabetes (ITD) moving from a glucose-only to a multi-metabolite monitoring - glucose, lactate and 3 ß OH-butyrate– paradigm. Multi-metabolite monitoring will also lead to a diabetes therapy breakthrough by algorithmically driving a continuous physiologic insulin delivery by a maintenance-free implanted MEMS pump using the peritoneal route enabling an optimal therapy for subjects with ITD.
Our vision is a fully implantable artificial organ to replace insulin secretion loss by targeting metabolic health instead of mere glucose control and mimicking physiological insulin action. While offering a really burden-free life for insulin-treated children and adults, it is expected to allow a dramatic reduction of metabolic variations, hence a minimization of acute and long-term complications and an abating of the still high mortality of T1D patients.
Unobtrusive living with diabetes will be reached by the calibration-free, implantable, long-term multi-metabolite monitoring solution connected wirelessly to a novel highly miniaturized silicon MEMS micropump, with down to 50 nl stroke volume, able to operate a newly developed U1000 insulin and enabling reservoir refill cycles of 180 days up to 365 days. Both devices hold durable battery operating life of more than 8 years without recharge and are suitable for children. Newly designed control algorithms based upon multiple signal inputs will drive automated insulin delivery without the need of obtrusive meal and physical exercise announcements.
Fields of science
Keywords
Programme(s)
- HORIZON.3.1 - The European Innovation Council (EIC) Main Programme
Funding Scheme
HORIZON-EIC - HORIZON EIC GrantsCoordinator
80686 Munchen
Germany