Shedding light on three-dimensional gene regulation

Información del proyecto

3D-REG

Identificador del acuerdo de subvención: 101115401

DOI

10.3030/101115401

Fecha de la firma de la CE 16 Octubre 2023

Fecha de inicio 1 Enero 2024

Fecha de finalización 31 Diciembre 2028

Financiado con arreglo a

• European Research Council (ERC)

Coste total

€ 1 500 000,00

Aportación de la UE

€ 1 500 000,00

Coordinado por

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

Periodic Reporting for period 1 - 3D-REG (Shedding light on three-dimensional gene regulation)

Período documentado: 2024-01-01 hasta 2026-06-30

Resumen del contexto y de los objetivos generales del proyecto

Complex organisms such as humans contain hundreds of different cell types that perform vastly different functions but are all instructed by the exact same DNA sequence. The specification of different cell types is dependent on precise regulation of the activity of the genes that are contained in our DNA. However, it remains unclear how specific sets of genes are switched on and off in order to support the development and functioning of specific cell types. It is known that genes make up a very small proportion of our DNA and that they are regulated by specific “non-coding” sequences in the DNA. Since these regulatory sequences can be located relatively far away from their target genes, DNA is folded in specific structures that allow for communication between these DNA sequences in 3D space. The 3D-REG research project aims to develop and apply cutting-edge techniques to identify the molecular mechanisms by which regulatory sequences communicate and regulate gene activity.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

So far, we have developed, established, and applied new, cutting-edge techniques that allow us to: (1) perturb potential regulatory proteins with very high temporal precision; (2) measure the effects on communication between regulatory sequences and other molecular gene regulatory events with very high spatial resolution; (3) characterize the proteins that are involved in gene regulation.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

We have developed and applied cutting-edge techniques to analyse gene regulation in its 3D context at high temporal and spatial resolution. Further development and implementation of these techniques are not only important to better understand the fundamental nature of gene regulation, but will ultimately also contribute to our understanding of the molecular basis of genetic disease.