Shedding light on three-dimensional gene regulation

Informacje na temat projektu

3D-REG

Identyfikator umowy o grant: 101115401

DOI

10.3030/101115401

Data podpisania przez KE 16 Października 2023

Data rozpoczęcia 1 Stycznia 2024

Data zakończenia 31 Grudnia 2028

Finansowanie w ramach

• European Research Council (ERC)

Koszt całkowity

€ 1 500 000,00

Wkład UE

€ 1 500 000,00

Koordynowany przez

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

Periodic Reporting for period 1 - 3D-REG (Shedding light on three-dimensional gene regulation)

Okres sprawozdawczy: 2024-01-01 do 2026-06-30

Podsumowanie kontekstu i ogólnych celów projektu

Complex organisms such as humans contain hundreds of different cell types that perform vastly different functions but are all instructed by the exact same DNA sequence. The specification of different cell types is dependent on precise regulation of the activity of the genes that are contained in our DNA. However, it remains unclear how specific sets of genes are switched on and off in order to support the development and functioning of specific cell types. It is known that genes make up a very small proportion of our DNA and that they are regulated by specific “non-coding” sequences in the DNA. Since these regulatory sequences can be located relatively far away from their target genes, DNA is folded in specific structures that allow for communication between these DNA sequences in 3D space. The 3D-REG research project aims to develop and apply cutting-edge techniques to identify the molecular mechanisms by which regulatory sequences communicate and regulate gene activity.

Prace wykonane od początku projektu do końca okresu sprawozdawczego oraz najważniejsze dotychczasowe rezultaty

So far, we have developed, established, and applied new, cutting-edge techniques that allow us to: (1) perturb potential regulatory proteins with very high temporal precision; (2) measure the effects on communication between regulatory sequences and other molecular gene regulatory events with very high spatial resolution; (3) characterize the proteins that are involved in gene regulation.

Innowacyjność oraz oczekiwany potencjalny wpływ (w tym dotychczasowe znaczenie społeczno-gospodarcze i szersze implikacje społeczne projektu)

We have developed and applied cutting-edge techniques to analyse gene regulation in its 3D context at high temporal and spatial resolution. Further development and implementation of these techniques are not only important to better understand the fundamental nature of gene regulation, but will ultimately also contribute to our understanding of the molecular basis of genetic disease.