Objective
The cytoskeleton is mainly composed of actin, microtubules, and intermediate filaments. It is fundamentally important for many cellular processes, which is reflected in its morphological and functional diversity. In the past, in-depth analysis of actin and microtubule networks made it possible to reconstitute their diversity in vitro with astonishing precision. This enabled a detailed understanding of the mechanisms underlying actin and microtubule network formation, which are the basis for many cellular processes.
In contrast, our knowledge of intermediate filaments is still in its infancy, and we are far from rebuilding complex intermediate filament networks and their interactions with other cytoskeletal elements in vitro. As intermediate filaments are a major determinant of cellular resilience against mechanical stress and their mutations associate with diseases, detailed insight into intermediate filament network formation and properties will represent a milestone in cytoskeletal research.
The proposed project will be a major step in this direction. We focus on vimentin, the most ubiquitous member of the intermediate filament family. We will investigate the role of vimentin-microtubule crosstalk as well as the relation between network morphology and mechanical stress. How do these networks provide cells with mechanical stability, while being able to rapidly change their morphology? Through a combination of biochemical, structuring, and mechanical methods we will address this question, which is relevant in many biological systems – from subcellular structures to tissues and organisms.
In this way, CROSSTALK will pave the way towards a clearer picture of this heavily understudied cytoskeletal filament. It aims at integrated, mechanistic insight into the organization and (mechanical) functions of vimentin and its interactions with microtubules, which form the basis for understanding its role in many higher-order physiological and pathological processes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
66123 Saarbrucken
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.