Objective
Decades of work established the importance of dormant cells in reproduction and regeneration, however, a central unsolved question is how the cell propagates transcriptional memory and cellular identity through dormancy. Current approaches tend to characterize dormancy as a binary on-off switch. In contrast, a highly coordinated and precisely timed set of events are needed to successfully transition cells into dormancy, to maintain dormancy, and to exit it. In DOR-CODE, I will leverage the latest gene editing and genome profiling tools on an inducible and reversible embryonic dormancy model that I spearheaded (Bulut-Karslioglu et al, 2016, van der Weijden et al, 2022) to discover the genomic basis of dormancy. My mission is to reveal the temporal regulatory code of dormancy - ‘DOR-CODE’ - without which cellular identity cannot be propagated through time.
Recent work by us and others has started to reveal the epigenomic landscape of dormancy: a highly repressed state with elevated DNA and histone methylation and decreased transcriptional output. Cellular strategies to counteract this overall repressive state at regulatory sites at the correct times are key for the retention of developmental potential. Here, I will identify DNA and histone demethylation strategies to propagate transcriptional memory at key regulatory elements (Objectives 1&2) and connect locus-specific regulation (Objectives 1&2) to genome macro-organization (Objective 3). By building direct links between anabolic growth and genome regulation, I will demonstrate how timely gene reactivation is ensured to enable exit from dormancy.
The conceptual leap and mechanistic insights resulting from DOR-CODE will (1) enhance our knowledge of embryonic dormancy and lay the foundation for better in vitro embryo preservation, (2) bring a fresh perspective to related systems such as regeneration, longevity, and cancer dormancy, and (3) fuel the research in my lab for decades to come.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology
- engineering and technology environmental engineering energy and fuels
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.