Objective "In modern industrial societies, myopia has become an important ocular health problem of young people, due to its increased incidence and associated complications, which pose a significant risk of blindness already in the middle life span. Current treatment options have limited effects with a maximum reduction of axial elongation by about 0.4 mm over several years, equivalent to a reduction in myopia by only about 1 D. Eye growth is controlled by an interplay of different biochemical pathways, one inhibitory (stimulated by image plane in front of the retina) and one stimulatory (image plane behind the retina). A novel future strategy would be to activate the inhibitory pathways rather than inhibit the growth stimulating pathways (standard target in most studies). At present, interventions to activate growth inhibition are poorly studied. The influence of environmental factors (spectral composition of ambient light) and gene-environment interactions (specific gene variants and their interaction with key lifestyle exposures) on eye growth and refractive development will be investigated. New pharmacological targets will be identified and tested, and biomarkers established to detect the onset of myopia at an earlier stage. It will be studied how choroidal hypoxia relates to choroidal thinning and axial eye growth and how it interacts with the metabolic processes in the retina and sclera. New measurement techniques will be developed that implement artificial intelligence algorithms to improve diagnostics in myopia studies, especially in the periphery of the visual field. The proposed intersectorial and interdisciplinary ""MyoTreat"" project (including anatomy, physiology, pharmacology, optics, and genetics) will train PhD students in myopia research and generate and disseminate novel research results. The ultimate scientific goal is to identify new strategies for myopia therapy through hypothesis-driven translational research in various animal models as well as in humans." Fields of science natural sciencescomputer and information sciencesartificial intelligencemedical and health sciencesclinical medicineophthalmologynatural sciencesphysical sciencesopticsmedical and health sciencesbasic medicinephysiologymedical and health sciencesbasic medicinepharmacology and pharmacy Keywords Myopia gene-environment interaction defocus detection pathway analysis hypoxia choroid Programme(s) HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme Topic(s) HORIZON-MSCA-2022-DN-01-01 - MSCA Doctoral Networks 2022 Call for proposal HORIZON-MSCA-2022-DN-01 See other projects for this call Funding Scheme HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks Coordinator EBERHARD KARLS UNIVERSITAET TUEBINGEN Net EU contribution € 521 078,40 Address GESCHWISTER-SCHOLL-PLATZ 72074 Tuebingen Germany See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Participants (5) Sort alphabetically Sort by Net EU contribution Expand all Collapse all CARL ZEISS VISION INTERNATIONAL GMBH Germany Net EU contribution € 521 078,40 Address TURNSTRASSE 27 73430 Aalen See on map Region Baden-Württemberg Stuttgart Ostalbkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands Net EU contribution € 274 370,40 Address DR MOLEWATERPLEIN 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data PARACELSUS MEDIZINISCHE PRIVATUNIVERSITAT SALZBURG - PRIVATSTIFTUNG Austria Net EU contribution € 270 331,20 Address STRUBERGASSE 21 5020 Salzburg See on map Region Westösterreich Salzburg Salzburg und Umgebung Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data UNIVERSITETET I SOROST-NORGE Norway Net EU contribution € 595 497,60 Address RAVEIEN 215 3184 BORRE See on map Region Norge Agder og Sør-Østlandet Vestfold og Telemark Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data SORBONNE UNIVERSITE France Net EU contribution € 565 387,20 Address 21 RUE DE L'ECOLE DE MEDECINE 75006 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partners (5) Sort alphabetically Sort by Net EU contribution Expand all Collapse all INSTITUT FUR MOLEKULARE UND KLINISCHE OPHTHALMOLOGIE BASEL Switzerland Net EU contribution € 0,00 Address C/O UNIVERSITÄTSSPITAL BASEL, AUGENKLINIK, MITTLERE STRASSE 4056 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data TRB Chemedica International SA Switzerland Net EU contribution € 0,00 Address Rue Michel-Servet 12 1206 Geneva See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data SIGNIFY NETHERLANDS BV Netherlands Net EU contribution € 0,00 Address HIGH TECH CAMPUS 45 5656 AE Eindhoven See on map Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data FOLKEHELSEINSTITUTTET Norway Net EU contribution € 0,00 Address LOVISENBERGGATA 8 0456 Oslo See on map Region Norge Oslo og Viken Oslo Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data CARDIFF UNIVERSITY United Kingdom Net EU contribution € 0,00 Address NEWPORT ROAD 30 36 CF24 0DE Cardiff See on map Region Wales East Wales Cardiff and Vale of Glamorgan Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data