Inhibition of tau neuronal internalization using anti-tau single domain antibodies
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Author(s):
Clément Danis, Elian Dupré, Thomas Bouillet, Marine Denéchaud, Camille Lefebvre, Marine Nguyen, Justine Mortelecque, François-Xavier Cantrelle, Jean-Christophe Rain, Xavier Hanoulle, Morvane Colin, Luc Buée, Isabelle Landrieu
Published in:
Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher:
Springer Science and Business Media LLC
DOI:
10.1038/S41467-025-58383-4
Tau profiling of brain extracellular vesicles reveals PHF6 peptide as core for pathological tau seeding in Alzheimer's disease
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Author(s):
Marie Oosterlynck, Laura Fichter, Elodie Leroux, Sabiha Eddarkaoui, Thomas Bouillet, Camille Lefebvre, Marine Nguyen, Claude-Alain Maurage, Bertrand Accart, Elian Dupré, Isabelle Landrieu, Clément Danis, Sylvain Lehmann, Jérôme Vialaret, Luc Buée, Christophe Hirtz, Morvane Colin
Published in:
Journal of Biomedical Science, Issue 33, 2026, ISSN 1423-0127
Publisher:
Springer Science and Business Media LLC
DOI:
10.1186/S12929-026-01250-1
Anti-tau VHH therapy against PHF6: a safe approach to slowing the phenotype of tau pathology
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Author(s):
Raphaelle Caillierez, Clémence Leboullenger, Sarah Leclercq, Mélanie Besegher, Séverine Bégard, Florent Auger, Claude-Alain Maurage, Bertrand Accart, Justine Mortelecque, Elian Dupré, Clément Danis, Isabelle Landrieu, Luc Buée, Morvane Colin
Published in:
Alzheimer's Research & Therapy, Issue 17, 2025, ISSN 1758-9193
Publisher:
Springer Science and Business Media LLC
DOI:
10.1186/S13195-025-01823-6
A Proline-Rich-Domain-Binding Single Domain Antibody Selectively Inhibits RNA-Induced Phase Separation of Tau
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Author(s):
Simon Thiou, Leslie Martin, Evangelia Manousaki, Marine Nguyen, Justine Mortelecque, Leila Heidsieck, François-Xavier Cantrelle, David Blum, Valérie Buée-Scherrer, Luc Buée, Isabelle Landrieu, Elian Dupré, Clément Danis
Published in:
ACS Chemical Neuroscience, Issue 17, 2026, ISSN 1948-7193
Publisher:
American Chemical Society (ACS)
DOI:
10.1021/ACSCHEMNEURO.6C00110
