Intrinsically disordered proteins in health and disease: mechanisms, molecular context and opportunities for drug discovery

Project Information

IDPro

Grant agreement ID: 101119633

DOI

10.3030/101119633

EC signature date 5 July 2023

Start date 1 September 2023

End date 31 August 2027

Funded under

• Marie Skłodowska-Curie Actions (MSCA)

Total cost

No data

EU contribution

€ 2 741 990,40

Coordinated by

UPPSALA UNIVERSITET
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (3)

Workshop 1 and 2
Summer school
Visit to TC test bed

Websites, patent fillings, videos etc. (1)

Website, twitter, facebook, LinkedIn

Publications

Peer reviewed articles (3)

Autoinhibition of untimely DNA binding by structural disorder in the full-length peroxisome proliferator-activated receptors (PPARs)

Author(s): Milena R. Lalic, Elisabeth G. K. Thomsen, F. Emil Thomasen, Aditya Udupa, Emma Salehian Andersen, Sonja Kuppermann, Casper G. Christensen, Emma Holm-Olesen, Daniel Saar, Andreas Prestel, Lukas W. Bauer, Joseph McKenna, Johan G. Olsen, Susanne Mandrup, Rasmus Hartmann-Petersen, Cy M. Jeffries, Max V. Staller, Kresten Lindorff-Larsen, Birthe B. Kragelund
Published in: Nature Communications, 2026, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-76962-X

A single buried cysteine acts as a hydrophobic stabilizer of a folding intermediate and transition state in the <scp>MATH</scp> domain of <scp>SPOP</scp>

Author(s): Pagano, Livia; Diop, Awa; Pennacchietti, Valeria; Di Felice, Mariana; Ventura, Eduarda S.; Toso, Julian; Toto, Angelo; Gianni, Stefano
Published in: Protein Science, 2025, ISSN 1469-896X
Publisher: Wiley
DOI: 10.1002/PRO.70138

Polypharmacological profiling across protein target families and cellular pathways using the multiplexed cell-based assay platform safetyProfiler reveals efficacy, potency and side effects of drugs

Author(s): Lukša Popović, Ben Brankatschk, Giulia Palladino, Moritz J. Rossner, Michael C. Wehr
Published in: Biomedicine &amp; Pharmacotherapy, Issue 180, 2024, ISSN 0753-3322
Publisher: Elsevier BV
DOI: 10.1016/J.BIOPHA.2024.117523