A single buried cysteine acts as a hydrophobic stabilizer of a folding intermediate and transition state in the <scp>MATH</scp> domain of <scp>SPOP</scp>
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Autoren:
Pagano, Livia; Diop, Awa; Pennacchietti, Valeria; Di Felice, Mariana; Ventura, Eduarda S.; Toso, Julian; Toto, Angelo; Gianni, Stefano
Veröffentlicht in:
Protein Science, 2025, ISSN 1469-896X
Herausgeber:
Wiley
DOI:
10.1002/PRO.70138
Polypharmacological profiling across protein target families and cellular pathways using the multiplexed cell-based assay platform safetyProfiler reveals efficacy, potency and side effects of drugs
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Autoren:
Lukša Popović, Ben Brankatschk, Giulia Palladino, Moritz J. Rossner, Michael C. Wehr
Veröffentlicht in:
Biomedicine & Pharmacotherapy, Ausgabe 180, 2024, ISSN 0753-3322
Herausgeber:
Elsevier BV
DOI:
10.1016/J.BIOPHA.2024.117523